(Q34427125)

2 August 2017

title

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures (English)

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2 August 2017

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Domenico Accili

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2 August 2017

Dieter Egli

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2 August 2017

Rudolph L Leibel

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2 August 2017

Ryotaro Bouchi

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2 August 2017

Kylie S Foo

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2 August 2017

Haiqing Hua

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2 August 2017

Kyoichiro Tsuchiya

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2 August 2017

Yoshiaki Ohmura

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2 August 2017

P Rodrigo Sandoval

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2 August 2017

Lloyd E Ratner

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2 August 2017

language of work or name

English

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publication date

30 June 2014

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2 August 2017

published in

Nature Communications

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2 August 2017

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2 August 2017

page(s)

4242

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De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts

2 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

iPSC-derived β cells model diabetes due to glucokinase deficiency

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

A scalable system for production of functional pancreatic progenitors from human embryonic stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

EphB3 marks delaminating endocrine progenitor cells in the developing pancreas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Generating human intestinal tissue from pluripotent stem cells in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Convergence of the insulin and serotonin programs in the pancreatic β-cell

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Generation of pluripotent stem cells from patients with type 1 diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Current view: intestinal stem cells and signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Minireview: Development and differentiation of gut endocrine cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Glucose-dependent insulin release from genetically engineered K cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083475

Generation of functional insulin-producing cells in the gut by Foxo1 ablation

6 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5242

Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5242

Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5242

Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5242

Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5242

Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5242

21 January 2018

Identifiers

DOI

10.1038/NCOMMS5242

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Dimensions Publication ID

2 August 2017

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2 August 2017

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