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Complement System Part I - Molecular Mechanisms of Activation and Regulation

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Europe PubMed Central

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2 August 2017

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Europe PubMed Central

Complement System Part I - Molecular Mechanisms of Activation and Regulation (English)

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Europe PubMed Central

PubMed publication ID

2 August 2017

Véronique Frémeaux-Bacchi

3

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Veronique Fremeaux-Bacchi

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Europe PubMed Central

PubMed publication ID

2 August 2017

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Nicolas S Merle

1

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Europe PubMed Central

PubMed publication ID

2 August 2017

Sarah Elizabeth Church

2

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Europe PubMed Central

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2 August 2017

Lubka T Roumenina

4

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Europe PubMed Central

PubMed publication ID

2 August 2017

publication date

2 June 2015

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Europe PubMed Central

PubMed publication ID

2 August 2017

Frontiers in Immunology

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Europe PubMed Central

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2 August 2017

6

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Europe PubMed Central

PubMed publication ID

2 August 2017

262

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Europe PubMed Central

PubMed publication ID

2 August 2017

Complement System Part II: Role in Immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement

1 reference

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6 July 2018

Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth

1 reference

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6 July 2018

Complementing the Sugar Code: Role of GAGs and Sialic Acid in Complement Regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C4a: An Anaphylatoxin in Name Only.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Interplay between fibrinolysis and complement: plasmin cleavage of iC3b modulates immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A revised mechanism for the activation of complement C3 to C3b: a molecular explanation of a disease-associated polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Deciphering the fine details of c1 assembly and activation mechanisms: "mission impossible"?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural basis for sialic acid-mediated self-recognition by complement factor H

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

von Willebrand factor is a cofactor in complement regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

In silico and in vitro studies on the protein-protein interactions between Brugia malayi immunomodulatory protein calreticulin and human C1q.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

IgGs are made for walking on bacterial and viral surfaces.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural and functional characterization of human and murine C5a anaphylatoxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement anaphylatoxin C4a inhibits C5a-induced neointima formation following arterial injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Molecular Interactions between Complement Factor H and Its Heparin and Heparan Sulfate Ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement is activated by IgG hexamers assembled at the cell surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The making of a macromolecular machine: assembly of the membrane attack complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

An internal ligand-bound, metastable state of a leukocyte integrin, α X β 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The proteoglycan glycomatrix: a sugar microenvironment essential for complement regulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Functional evaluation of factor H genetic and acquired abnormalities: application for atypical hemolytic uremic syndrome (aHUS).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Meningococcal disease and the complement system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Disruption of the complement anaphylatoxin receptor C5L2 exacerbates inflammation in allergic contact dermatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Toward a structure-based comprehension of the lectin pathway of complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The Serine Protease Domain of MASP-3: Enzymatic Properties and Crystal Structure in Complex with Ecotin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Physiological and therapeutic complement regulators in kidney transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement factor H related proteins (CFHRs)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H2O).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Properdin and factor h: opposing players on the alternative complement pathway "see-saw".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Rational engineering of a minimized immune inhibitor with unique triple-targeting properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement in immune and inflammatory disorders: therapeutic interventions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural and functional overview of the lectin complement pathway: its molecular basis and physiological implication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Dimerization of complement factor H-related proteins modulates complement activation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Bradykinin and the pathogenesis of hereditary angioedema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Arranged sevenfold: structural insights into the C-terminal oligomerization domain of human C4b-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C5L2 and C5aR interaction in adipocytes and macrophages: insights into adipoimmunology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Human and pneumococcal cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins are both ligands of human C1q protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The tick-over theory revisited: is C3 a contact-activated protein?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural basis for activation of the complement system by component C4 cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Regulation of humoral immunity by complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Annexin A2 and A5 serve as new ligands for C1q on apoptotic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C1q and phagocytosis: the perfect complement to a good meal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The human c1q globular domain: structure and recognition of non-immune self ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Plasminogen is a complement inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Molecular basis for complement recognition by integrin αXβ2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The innate immune response to products of phospholipid peroxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Genetics of hemolytic uremic syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement factor H-ligand interactions: self-association, multivalency and dissociation constants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Integrin inside-out signaling and the immunological synapse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural basis for complement factor I control and its disease-associated sequence polymorphisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Alternative pathway activation of complement by Shiga toxin promotes exuberant C3a formation that triggers microvascular thrombosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Heme interacts with c1q and inhibits the classical complement pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural basis for engagement by complement factor H of C3b on a self surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Alternative complement pathway assessment in patients with atypical HUS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structures of C3b in complex with factors B and D give insight into complement convertase formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and Pathogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Molecular intercommunication between the complement and coagulation systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement: a key system for immune surveillance and homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of human desArg-C5a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Properdin: emerging roles of a pattern-recognition molecule.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Atypical hemolytic-uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Stringent regulation of complement lectin pathway C3/C5 convertase by C4b-binding protein (C4BP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Thrombomodulin mutations in atypical hemolytic-uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of complement fragment C3b-factor H and implications for host protection by complement regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The role of the anaphylatoxins in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Compstatin: a complement inhibitor on its way to clinical application

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Interaction between the coagulation and complement system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C1, MBL-MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Modulation of the antitumor immune response by complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A role of macrophage complement receptor CRIg in immune clearance and inflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A new map of glycosaminoglycan and C3b binding sites on factor H

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The alternative complement pathway revisited

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The tick-over theory revisited: formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement driven by conformational changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Hematin promotes complement alternative pathway-mediated deposition of C3 activation fragments on human erythrocytes: potential implications for the pathogenesis of anemia in malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural basis for complement factor H linked age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

High-resolution structures of bacterially expressed soluble human CD59

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Macrophage complement receptors and pathogen clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C1q and its growing family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Factor B structure provides insights into activation of the central protease of the complement system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Beta-arrestins and cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural transitions of complement component C3 and its activation products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of C3b in complex with CRIg gives insights into regulation of complement activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

VSIG4, a B7 family-related protein, is a negative regulator of T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Defining the CD59-C9 binding interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

M-ficolin, an innate immune defence molecule, binds patterns of acetyl groups and activates complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Platelet activation leads to activation and propagation of the complement system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Essential role for the second extracellular loop in C5a receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement factor H polymorphism in age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement factor H polymorphism and age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement factor H variant increases the risk of age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Solvent accessibility of native and hydrolyzed human complement protein 3 analyzed by hydrogen/deuterium exchange and mass spectrometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural and functional anatomy of the globular domain of complement protein C1q.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

L-ficolin is a pattern recognition molecule specific for acetyl groups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure and activation of the C1 complex of complement: unraveling the puzzle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Functional analysis in serum from atypical Hemolytic Uremic Syndrome patients reveals impaired protection of host cells associated with mutations in factor H.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Carboxypeptidase N: a pleiotropic regulator of inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Interaction of the C1 complex of complement with sulfated polysaccharide and DNA probed by single molecule fluorescence microscopy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C5L2, a nonsignaling C5A binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Formation of high affinity C5 convertase of the classical pathway of complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Beyond lysis: how complement influences cell fate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure and function of complement C5 convertase enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural and functional characterization of factor H mutations associated with atypical hemolytic uremic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Generation of C5a by phagocytic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure, function and molecular genetics of human and murine C1r.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural requirements for the intracellular subunit polymerization of the complement inhibitor C4b-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure-function analysis of decay-accelerating factor: identification of residues important for binding of the Escherichia coli Dr adhesin and complement regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

CD59 blocks not only the insertion of C9 into MAC but inhibits ion channel formation by homologous C5b-8 as well as C5b-9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Phagocytosis of microbes: complexity in action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Continual low-level activation of the classical complement pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural biology of C1: dissection of a complex molecular machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of complement receptor 2 in complex with its C3d ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement. Second of two parts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Identification of four novel human G protein-coupled receptors expressed in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

An activation switch in the ligand binding pocket of the C5a receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Decay accelerating activity of complement receptor type 1 (CD35). Two active sites are required for dissociating C5 convertases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A cluster of positively charged amino acids in the C4BP alpha-chain is crucial for C4b binding and factor I cofactor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

FHL-1/reconectin: a human complement and immune regulator with cell-adhesive function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Human T cells express the C5a receptor and are chemoattracted to C5a.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Identification of residues within the 727-767 segment of human complement component C3 important for its interaction with factor H and with complement receptor 1 (CR1, CD35).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Solution structure of Compstatin, a potent complement inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Roles of phospholipase C β2 in chemoattractant-elicited responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A second serine protease associated with mannan-binding lectin that activates complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The internal thioester and the covalent binding properties of the complement proteins C3 and C4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Interaction between complement subcomponent C1q and the Klebsiella pneumoniae porin OmpK36.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

C3d of complement as a molecular adjuvant: bridging innate and acquired immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Novel function of C4a anaphylatoxin. Release from monocytes of protein which inhibits monocyte chemotaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Properdin, a positive regulator of complement activation, is expressed in human T cell lines and peripheral blood T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A unique property of a plasma proteoglycan, the C1q inhibitor. An anticoagulant state resulting from its binding to fibrinogen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Evidence that the extracellular N-terminal domain of C5aR contains amino-acid residues crucial for C5a binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Expression of properdin in human monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Specificity of the thioester-containing reactive site of human C3 and its significance to complement activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Mapping of the C5a receptor signal transduction network in human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Chronic myelogenous leukemia‐derived basophilic granulocytes express a functional active receptor for the anaphylatoxin C3a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of a soluble, glycosylated form of the human complement regulatory protein CD59

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure and function of decay accelerating factor CD55.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Physiologic inactivation of fluid phase C3b: isolation and structural analysis of C3c, C3d,g (alpha 2D), and C3g

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Cytolysis of nucleated cells by complement: cell death displays multi-hit characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Characterization of the interaction of human C4b-binding protein with physiological ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Rat brain Thy-1 glycoprotein. The amino acid sequence, disulphide bonds and an unusual hydrophobic region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The recovery of human polymorphonuclear leucocytes from sublytic complement attack is mediated by changes in intracellular free calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The membrane attack complex of complement: relation of C7 to the metastable membrane binding site of the intermediate complex C5b-7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The C3 convertase of the alternative pathway of human complement. Enzymic properties of the bimolecular proteinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Formation of transmural complement pores in serum-sensitive Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement membrane attack on nucleated cells: resistance, recovery and non-lethal effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

SC5b-7, SC5b-8 and SC5b-9 complexes of complement: ultrastructure and localization of the S-protein (vitronectin) within the macromolecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement C5a activation of phospholipase D in human neutrophils. A major route to the production of phosphatidates and diglycerides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Interaction of iC3b with recombinant isotypic and chimeric forms of CR2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Covalent binding of C3b to C4b within the classical complement pathway C5 convertase. Determination of amino acid residues involved in ester linkage formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Complement lysis: a hole is a hole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Control of the amplification convertase of complement by the plasma protein beta1H

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Histamine-induced inhibition of normal human basophil chemotaxis to C5a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Restriction of complement-mediated membrane damage by the eighth component of complement: a dual role for C8 in the complement attack sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Modulation of the alternative complement pathways by beta 1 H globulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

A molecular concept of the properdin pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

The influence of C3b inactivator (KAF) concentration on the ability of serum to support complement activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

6 July 2018

Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

The amplification loop of the complement pathways.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Role of Ca2+in the Electrostatic Stability and the Functional Activity of the Globular Domain of Human C1q†

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Interaction of human C1q with IgG and IgM: revisited

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Interaction of the globular domain of human C1q with Salmonella typhimurium lipopolysaccharide.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

The lectin-like activity of human C1q and its implication in DNA and apoptotic cell recognition

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Interaction of C1q with the receptor calreticulin requires a conformational change in C1q.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Toward a structure-based comprehension of the lectin pathway of complement

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Complement C1q-target proteins recognition is inhibited by electric moment effectors.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

The classical activation pathway of the human complement system is specifically inhibited by calreticulin from Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

The control of the complement lectin pathway activation revisited: both C1-inhibitor and antithrombin are likely physiological inhibitors, while α2-macroglobulin is not.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Differential substrate and inhibitor profiles for human MASP-1 and MASP-2.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

The role of properdin in the assembly of the alternative pathway C3 convertases of complement

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Myeloperoxidase directs properdin-mediated complement activation.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Properdin plays a protective role in polymicrobial septic peritonitis.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Structural requirements for the complement regulatory activities of C4BP.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Mutations in alpha-chain of C4BP that selectively affect its factor I cofactor function

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55).

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Multimeric interactions between complement factor H and its C3d ligand provide new insight on complement regulation

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Localization of the third heparin-binding site in the human complement regulator factor H1.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Formation of covalently linked C3-C3 dimers on IgG immune aggregates

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Live cell imaging of outward and inward vesiculation induced by the complement c5b-9 complex

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Two different transduction pathways are activated by C3a and C5a anaphylatoxins on astrocytes

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Structure-function relationships of human C5a and C5aR.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

C5L2 is required for C5a-triggered receptor internalization and ERK signaling

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Eculizumab in atypical hemolytic-uremic syndrome

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

An engineered construct combining complement regulatory and surface-recognition domains represents a minimal-size functional factor H.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Solution structure of TT30, a novel complement therapeutic agent, provides insight into its joint binding to complement C3b and C3d.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

C1 inhibitor, a multi-functional serine protease inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

27 October 2018

Characterization of C3a anaphylatoxin receptor on guinea-pig macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451739

27 October 2018

Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46)

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Relative Contribution of C1q and Apoptotic Cell-Surface Calreticulin to Macrophage Phagocytosis

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Generation of C5a in the absence of C3: a new complement activation pathway

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00262

21 January 2018

Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C5 convertase of the alternative complement pathway: covalent linkage between two C3b molecules within the trimolecular complex enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Weibel-Palade bodies--sentinels of acute stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of human neutrophils by C3a and C5A. Comparison of the effects on shape changes, chemotaxis, secretion, and respiratory burst

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Each of the three binding sites on complement factor H interacts with a distinct site on C3b

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the natural polymeric forms of human properdin and their functions in complement activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hereditary angio-oedema

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the second heparin-binding domain in human complement factor H

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-association and domain rearrangements between complement C3 and C3u provide insight into the activation mechanism of C3

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface-dependent modulation by H of C5 cleavage by the cell-bound alternative pathway C5 convertase of human complement

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody density on rat red cells determines the rate of activation of the complement component C1

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recovery of human neutrophils from complement attack: removal of the membrane attack complex by endocytosis and exocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new role for C-1-inhibitor in homeostasis: control of activation of the first component of human complement

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on human chromosome 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the early components of the classical complement pathway under physiologic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement receptor of the Ig superfamily enhances complement-mediated phagocytosis in a subpopulation of tissue resident macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane cofactor protein: importance of N- and O-glycosylation for complement regulatory function

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-function analysis of the active sites of complement receptor type 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of the second component of complement by plasma proteases: implications in hereditary C1-inhibitor deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compstatin inhibits complement and cellular activation in whole blood in two models of extracorporeal circulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A serum protein SP40,40 modulates the formation of membrane attack complex of complement on erythrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotaxis by mouse macrophage cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Existence of Different but Overlapping IgG- and IgM-Binding Sites on the Globular Domain of Human C1q†

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigations on the C1q–Calreticulin–Phosphatidylserine Interactions Yield New Insights into Apoptotic Cell Recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement--tapping into new sites and effector systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant and native zymogen forms of human complement factor D

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement C3b/C3d and cell surface polyanions are recognized by overlapping binding sites on the most carboxyl-terminal domain of complement factor H

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/26082779

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FIMMU.2015.00262

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

0 references

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