(Q34333826)

1 August 2017

title

Target validation using chemical probes (English)

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1 August 2017

Lyn H Jones

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Mark E Bunnage

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1 August 2017

Eugene L Piatnitski Chekler

series ordinal

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1 August 2017

publication date

1 April 2013

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1 August 2017

published in

Nature Chemical Biology

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

195-199

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The art of the chemical probe

1 August 2017

cites work

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Probing the probes: fitness factors for small molecule tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Pharmacodynamic biomarkers for molecular cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

The subcellular distribution of small molecules: from pharmacokinetics to synthetic biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

In-cell click labelling of small molecules to determine subcellular localisation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Structural bioinformatics-based design of selective, irreversible kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

A clickable inhibitor reveals context-dependent autoactivation of p90 RSK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Designing zebrafish chemical screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Zebrafish developmental screening of the ToxCast™ Phase I chemical library.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Identification of a novel retinoid by small molecule screening with zebrafish embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Drugs that induce repolarization abnormalities cause bradycardia in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

β-Catenin 1 and β-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Suppression of inflammation by a synthetic histone mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Recognizing and exploiting differences between RNAi and small-molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1197

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23508172

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Getting pharmaceutical R&D back on target

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23508172

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1197

1 reference

1 August 2017

1 reference