(Q34328654)

1 August 2017

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title

Application of in silico approaches to predicting drug--drug interactions (English)

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1 August 2017

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1 August 2017

Wrighton SA

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1 August 2017

publication date

1 January 2001

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Journal of Pharmacological and Toxicological Methods

1 August 2017

published in

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

65-69

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Molecular modeling of mammalian cytochrome P450s

1 August 2017

cites work

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7 January 2021

A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6

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7 January 2021

Novel approach to predicting P450-mediated drug metabolism: development of a combined protein and pharmacophore model for CYP2D6

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7 January 2021

Theoretical investigation of substrate specificity for cytochromes P450 IA2, P450 IID6 and P450 IIIA4

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7 January 2021

Present and future in vitro approaches for drug metabolism.

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7 January 2021

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7 January 2021

QSAR of P450 oxidation: on the value of comparing kcat and km with kcat/km

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7 January 2021

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Quantitative Structure-Activity Relationships in Substrates, Inducers, and Inhibitors of Cytochrome P4501 (CYP1)

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7 January 2021

On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human p450 substrate specificity and metabolism

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7 January 2021

Structural characteristics of human P450s involved in drug metabolism: QSARs and lipophilicity profiles

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7 January 2021

Structural determinants of cytochrome P450 substrate specificity, binding affinity and catalytic rate

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7 January 2021

Molecular modelling and quantitative structure-activity relationship studies on the interaction of omeprazole with cytochrome P450 isozymes

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7 January 2021

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

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A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions

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7 January 2021

Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes

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7 January 2021

Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies

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7 January 2021

Molecular modeling of mammalian cytochromes P450: application to study enzyme function

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7 January 2021

Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450

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The human hepatic cytochromes P450 involved in drug metabolism

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7 January 2021

10.1016/S1056-8719(01)00119-8

Identifiers

DOI

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1 August 2017

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