(Q34230157)

31 July 2017

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title

Spatial organization of gene expression: the active chromatin hub. (English)

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31 July 2017

Wouter de Laat

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Frank Grosveld

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31 July 2017

publication date

1 January 2003

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31 July 2017

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

447-459

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Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci

31 July 2017

cites work

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12 December 2020

Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice.

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12 December 2020

A position-effect assay for boundaries of higher order chromosomal domains

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12 December 2020

Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.

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12 December 2020

Self-association of the Drosophila zeste protein is responsible for transvection effects

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12 December 2020

GAGA can mediate enhancer function in trans by linking two separate DNA molecules

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12 December 2020

Developmental regulation of beta-globin gene switching.

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12 December 2020

Looping and interaction between hypersensitive sites in the active beta-globin locus

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12 December 2020

The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation

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12 December 2020

Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin

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12 December 2020

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

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12 December 2020

Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice

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12 December 2020

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

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12 December 2020

Transcriptional regulation at a distance in bacteria

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12 December 2020

The mouse beta-globin locus control region: hypersensitive sites 3 and 4

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12 December 2020

Long-range chromatin regulatory interactions in vivo

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12 December 2020

Insulators: many functions, many mechanisms.

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12 December 2020

Braking the silence: how heterochromatic gene repression is stopped in its tracks.

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12 December 2020

Analysis of mice with single and multiple copies of transgenes reveals a novel arrangement for the lambda5-VpreB1 locus control region

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12 December 2020

Histone methylation versus histone acetylation: new insights into epigenetic regulation

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12 December 2020

An enhancer stimulates transcription in trans when attached to the promoter via a protein bridge

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12 December 2020

Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus

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12 December 2020

The 87A7 chromomere. Identification of novel chromatin structures flanking the heat shock locus that may define the boundaries of higher order domains

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12 December 2020

Nipped-B, a Drosophila homologue of chromosomal adherins, participates in activation by remote enhancers in the cut and Ultrabithorax genes.

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12 December 2020

Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly.

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12 December 2020

Functional gene expression domains: defining the functional unit of eukaryotic gene regulation

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12 December 2020

Transvection in the Drosophila Abd-B domain: extensive upstream sequences are involved in anchoring distant cis-regulatory regions to the promoter

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12 December 2020

Setting the boundaries of chromatin domains and nuclear organization

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12 December 2020

Structural and dynamic functions establish chromatin domains.

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12 December 2020

An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene

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12 December 2020

Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing.

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12 December 2020

Physical linkage of the human growth hormone gene cluster and the skeletal muscle sodium channel alpha-subunit gene (SCN4A) on chromosome 17.

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12 December 2020

The chicken lysozyme chromatin domain contains a second, widely expressed gene

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12 December 2020

Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain

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12 December 2020

Clustering of housekeeping genes provides a unified model of gene order in the human genome

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12 December 2020

Epigenetic inheritance of active chromatin after removal of the main transactivator.

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12 December 2020

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

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12 December 2020

Transcription complex stability and chromatin dynamics in vivo

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12 December 2020

Importance of globin gene order for correct developmental expression.

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12 December 2020

A group of scs elements function as domain boundaries in an enhancer-blocking assay

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12 December 2020

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.

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12 December 2020

The effect of distance on long-range chromatin interactions

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12 December 2020

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

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12 December 2020

Characterization of the transvection mediating region of the abdominal-B locus in Drosophila.

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12 December 2020

Individual LCR hypersensitive sites cooperate to generate an open chromatin domain spanning the human beta-globin locus

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12 December 2020

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

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12 December 2020

Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers.

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12 December 2020

Conserved CTCF insulator elements flank the mouse and human beta-globin loci

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12 December 2020

An enhancer/locus control region is not sufficient to open chromatin

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12 December 2020

The human beta-globin locus control region confers an early embryonic erythroid-specific expression pattern to a basic promoter driving the bacterial lacZ gene.

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12 December 2020

Locus control region function and heterochromatin-induced position effect variegation

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12 December 2020

A novel cis-regulatory element, the PTS, mediates an anti-insulator activity in the Drosophila embryo

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12 December 2020

Different core promoters possess distinct regulatory activities in the Drosophila embryo

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12 December 2020

Dynamics of enhancer-promoter communication during differentiation-induced gene activation

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12 December 2020

Transactivation of the Xenopus rRNA gene promoter by its enhancer

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12 December 2020

Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect

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12 December 2020

CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1.

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12 December 2020

Locus control regions: coming of age at a decade plus

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12 December 2020

Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila

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12 December 2020

Physical linkage of the human growth hormone gene cluster and the CD79b (Ig beta/B29) gene

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12 December 2020

Making contacts on a nucleic acid polymer

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12 December 2020

Chromosomal boundaries in S. cerevisiae.

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12 December 2020

Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster

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12 December 2020

Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse beta-globin locus control region

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12 December 2020

Chromatin domains constitute regulatory units for the control of eukaryotic genes

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12 December 2020

Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci

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12 December 2020

Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs.

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12 December 2020

Substitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic mice

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12 December 2020

Capturing chromosome conformation

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12 December 2020

CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms

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12 December 2020

Developmental regulation of eukaryotic gene loci: which cis-regulatory information is required?

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12 December 2020

Immunoglobulin heavy-chain and CD3 delta-chain gene enhancers are DNase I-hypersensitive in hemopoietic progenitor cells.

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12 December 2020

Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus.

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12 December 2020

The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes

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12 December 2020

Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and deltabeta-thalassemia affects beta- but not gamma-globin gene expression

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12 December 2020

A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta -globin locus

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12 December 2020

UASrpg can function as a heterochromatin boundary element in yeast

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12 December 2020

The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

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12 December 2020

Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice

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12 December 2020

On the submicroscopic structure of chromosomes

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12 December 2020

Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region

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12 December 2020

A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

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12 December 2020

GAGA mediates the enhancer blocking activity of the eve promoter in the Drosophila embryo.

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12 December 2020

The gypsy insulator can act as a promoter-specific transcriptional stimulator

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12 December 2020

Effects of altered gene order or orientation of the locus control region on human beta-globin gene expression in mice.

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12 December 2020

Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene

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12 December 2020

The human transcriptome map: clustering of highly expressed genes in chromosomal domains

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12 December 2020

The beta-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice.

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12 December 2020

Identifiers

DOI

10.1023/A:1024922626726

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Dimensions Publication ID

31 July 2017

1047987941

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