(Q34293466)

1 August 2017

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title

Age-related changes in lymphocyte development and function (English)

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1 August 2017

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Phyllis Jean Linton

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1 August 2017

Kenneth Dorshkind

series ordinal

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1 August 2017

language of work or name

English

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publication date

1 February 2004

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

133-139

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BIOLOGY OF HEMATOPOIETIC STEM CELLS AND PROGENITORS: Implications for Clinical Application

1 August 2017

cites work

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The aging of lympho-hematopoietic stem cells

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Genetically determined variation in the number of phenotypically defined hematopoietic progenitor and stem cells and in their response to early-acting cytokines

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A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover

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A genetic determinant that specifically regulates the frequency of hematopoietic stem cells.

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The aging of hematopoietic stem cells

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Long-term erythropoietic repopulating ability of old, young, and fetal stem cells

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In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyte progenitors.

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Age-associated characteristics of murine hematopoietic stem cells

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The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors

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The Endocrinology of Aging

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Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution

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B cell development pathways

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7 January 2021

Aging and developmental transitions in the B cell lineage

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7 January 2021

Peripheral B cell selection and homeostasis

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7 January 2021

Impaired rearrangement of IgH V to DJ segments in bone marrow Pro-B cells from old mice

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7 January 2021

Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice

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7 January 2021

The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins

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7 January 2021

Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire.

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7 January 2021

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

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Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration

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Transitional B cells: step by step towards immune competence

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Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice

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The affinity and spectrum of cross reactivity of anti-body production in senescent mice: The IgM response

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The repertoire diversity and magnitude of antibody responses to bacterial antigens in aged mice: I. Age-associated changes in antibody responses differ according to the mouse strain.

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Immunosenescence and germinal center reaction

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Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice.

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7 January 2021

The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes

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Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice

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7 January 2021

Aging of the lymphoid system at the organ level. With special reference to the bone marrow as site of antibody production

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7 January 2021

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.

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Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice

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Gated Importation of Prothymocytes by Adult Mouse Thymus Is Coordinated with Their Periodic Mobilization from Bone Marrow

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7 January 2021

A positive look at double-negative thymocytes

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7 January 2021

The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection

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Generation of functional thymocytes in the human adult.

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7 January 2021

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Age-associated thymic atrophy is not associated with a deficiency in the CD44(+)CD25(-)CD3(-)CD4(-)CD8(-) thymocyte population

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7 January 2021

The pattern of T lymphocyte differentiation is altered during thymic involution

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7 January 2021

Early Steps in T Cell Development Are Affected by Aging

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7 January 2021

Thymopoiesis independent of common lymphoid progenitors

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7 January 2021

Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential

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Thymic atrophy in the mouse is a soluble problem of the thymic environment.

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Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution

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Age-associated thymic atrophy is linked to a decline in IL-7 production

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7 January 2021

Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments

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Lymphostromal interactions in thymic development and function

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Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus

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7 January 2021

Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes

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7 January 2021

One for all and all for one: thymic epithelial stem cells and regeneration

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7 January 2021

Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells

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7 January 2021

Hypertrophy of the thymus and restoration of immune functions in mice and rats by gonadectomy

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7 January 2021

GH3 pituitary adenoma cells can reverse thymic aging in rats

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7 January 2021

Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone.

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7 January 2021

Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice

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7 January 2021

CD8 T cells and aging

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7 January 2021

The aging of the immune system.

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7 January 2021

Antigen-independent changes in naive CD4 T cells with aging

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7 January 2021

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

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7 January 2021

Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection

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7 January 2021

Defective generation but normal maintenance of memory T cells in old mice.

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7 January 2021

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

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7 January 2021

Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A.

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7 January 2021

Early activation defects in T lymphocytes from aged mice

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7 January 2021

T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy.

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7 January 2021

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7 January 2021

Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice

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7 January 2021

Long-term immunological memory against viruses

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7 January 2021

Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals.

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7 January 2021

Induction of bystander T cell proliferation by viruses and type I interferon in vivo

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7 January 2021

Cutting edge: impaired Toll-like receptor expression and function in aging

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7 January 2021

Impact of aging on innate immunity

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7 January 2021

The frail elderly: role of dendritic cells in the susceptibility of infection

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7 January 2021

Effect of aging on epidermal dendritic cell populations in C57BL/6J mice

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7 January 2021

NK and NK/T cells in human senescence

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7 January 2021

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7 January 2021

Aging and the hemopoietic system.

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7 January 2021

Identifiers

DOI

10.1038/NI1033

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1 August 2017

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