(Q34276613)

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Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)

scientific article published on October 7, 2010

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Europe PubMed Central

PubMed publication ID

1 August 2017

Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM) (English)

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Europe PubMed Central

PubMed publication ID

1 August 2017

mitochondrial DNA

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Lon protease Dmel_CG8798

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GOA release 2020-03-11

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Yuichi Matsushima

1

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Europe PubMed Central

PubMed publication ID

1 August 2017

Yu-ichi Goto

2

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Europe PubMed Central

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1 August 2017

Laurie S. Kaguni

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20930118

29 July 2024

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7 October 2010

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1 August 2017

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https://europepmc.org/articles/pmc2972957?pdf=render

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20930118

29 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20930118/pdf/?tool=EBI

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content deliverer

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20930118

29 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20930118/?tool=EBI

online access status

content deliverer

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20930118

29 July 2024

https://europepmc.org/articles/PMC2972957

online access status

content deliverer

Europe PubMed Central

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20930118

29 July 2024

https://europepmc.org/articles/PMC2972957?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20930118

29 July 2024

https://doi.org/10.1073/pnas.1008924107

online access status

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20930118

29 July 2024

https://pnas.org/doi/pdf/10.1073/pnas.1008924107

1 reference

10.1073/PNAS.1008924107

https://api.crossref.org/works/10.1073/PNAS.1008924107

29 July 2024

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

1 August 2017

107

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Europe PubMed Central

PubMed publication ID

1 August 2017

43

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

18410-18415

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Regulation and quality control by Lon-dependent proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Mitochondrial protein homeostasis: the cooperative roles of chaperones and proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Mitochondrial Lon protease is a human stress protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Physiological and biochemical defects in carboxyl-terminal mutants of mitochondrial DNA helicase

1 reference

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6 July 2018

Mitochondrial protein quality control: implications in ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Functional analysis by inducible RNA interference in Drosophila melanogaster

1 reference

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6 July 2018

The layered structure of human mitochondrial DNA nucleoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Importance of the lon protease in mitochondrial maintenance and the significance of declining lon in aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

HIV and mitochondrial toxicity in children

1 reference

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6 July 2018

Evolutionary tinkering with mitochondrial nucleoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Protein degradation within mitochondria: versatile activities of AAA proteases and other peptidases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

ClpP: a distinctive family of cylindrical energy-dependent serine proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Differential phenotypes of active site and human autosomal dominant progressive external ophthalmoplegia mutations in Drosophila mitochondrial DNA helicase expressed in Schneider cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Biological roles of the Lon ATP-dependent protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Oligomeric structure of the ATP-dependent protease La (Lon) of Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Dynamic assembly, localization and proteolysis of the Bacillus subtilis SMC complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Cleavage site selection within a folded substrate by the ATP-dependent lon protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Drosophila mitochondrial transcription factor B1 modulates mitochondrial translation but not transcription or DNA copy number in Schneider cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Comparative genomics and functional roles of the ATP-dependent proteases Lon and Clp during cytosolic protein degradation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Drosophila mitochondrial transcription factor B2 regulates mitochondrial DNA copy number and transcription in schneider cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

DNA and RNA binding by the mitochondrial lon protease is regulated by nucleotide and protein substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Functional domains of chicken mitochondrial transcription factor A for the maintenance of mitochondrial DNA copy number in lymphoma cell line DT40.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Composition and dynamics of human mitochondrial nucleoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Human mitochondrial DNA is packaged with TFAM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA

1 reference

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6 July 2018

Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells

1 reference

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6 July 2018

What regulates mitochondrial DNA copy number in animal cells?

1 reference

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6 July 2018

Drosophila mitochondrial transcription factor A (d-TFAM) is dispensable for the transcription of mitochondrial DNA in Kc167 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits

1 reference

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6 July 2018

Functional interactions of mitochondrial DNA polymerase and single-stranded DNA-binding protein. Template-primer DNA binding and initiation and elongation of DNA strand synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

The human LON protease binds to mitochondrial promoters in a single-stranded, site-specific, strand-specific manner

1 reference

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6 July 2018

Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme

1 reference

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6 July 2018

PIM1 encodes a mitochondrial ATP-dependent protease that is required for mitochondrial function in the yeast Saccharomyces cerevisiae.

1 reference

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6 July 2018

Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972957

6 July 2018

Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae

1 reference

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21 January 2018

PDIP38 Associates with Proteins Constituting the Mitochondrial DNA Nucleoid

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008924107

21 January 2018

Identifiers

10.1073/PNAS.1008924107

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

2010PNAS..10718410M

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

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