(Q34249024)

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B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins

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Europe PubMed Central

PubMed publication ID

31 July 2017

B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins (English)

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Europe PubMed Central

PubMed publication ID

31 July 2017

apoptotic process

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Thibaud T. Renault

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Thibaud T Renault

1

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Jerry E. Chipuk

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Jerry E Chipuk

4

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author name string

Rana Elkholi

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

Archana Bharti

3

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Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

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publication date

5 August 2014

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Europe PubMed Central

PubMed publication ID

31 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

31 July 2017

289

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Europe PubMed Central

PubMed publication ID

31 July 2017

38

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Europe PubMed Central

PubMed publication ID

31 July 2017

26481-26491

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Europe PubMed Central

PubMed publication ID

31 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4176207/fullTextXML

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Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAF(V600E) inhibition and can be targeted to reduce resistance.

1 reference

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1 reference

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1 reference

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1 reference

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PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

1 reference

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1 reference

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Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.

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The BCL-2 family reunion

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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ER stress triggers apoptosis by activating BH3-only protein Bim

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176207

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1 reference

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

1 reference

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

1 reference

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1 reference

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

1 reference

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1 reference

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Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release

1 reference

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6 July 2018

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

1 reference

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1 reference

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176207

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

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1 reference

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176207

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HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.569632

21 January 2018

Expression, purification and use of recombinant annexin V for the detection of apoptotic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.569632

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Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/25096574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/25096574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M114.569632

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

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