(Q34139125)

31 July 2017

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title

Metabonomics: a platform for studying drug toxicity and gene function (English)

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31 July 2017

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Jeremy K Nicholson

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Elaine Holmes

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31 July 2017

John Connelly

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31 July 2017

John C Lindon

series ordinal

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31 July 2017

publication date

1 February 2002

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Nature Reviews Drug Discovery

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

153-161

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'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

31 July 2017

cites work

1 reference

Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks

31 March 2020

1 reference

Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants

31 March 2020

1 reference

Pattern recognition analysis of high resolution 1H NMR spectra of urine. A nonlinear mapping approach to the classification of toxicological data

31 March 2020

1 reference

Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the Fischer 344 rat

31 March 2020

1 reference

Abnormal lipid profile of dystrophic cardiac tissue as demonstrated by one- and two-dimensional magic-angle spinning (1)H NMR spectroscopy

31 March 2020

1 reference

Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity

31 March 2020

1 reference

The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine

31 March 2020

1 reference

Chemometric Models for Toxicity Classification Based on NMR Spectra of Biofluids

31 March 2020

1 reference

An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse

31 March 2020

1 reference

Metabolic profiling of genetic disorders: a multitissue (1)H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue

31 March 2020

1 reference

Key challenges for toxicologists in the 21st century

31 March 2020

1 reference

Towards a truly integrative biology through the functional genomics of yeast

31 March 2020

1 reference

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

31 March 2020

1 reference

The yeast genome: on the road to the Golden Age.

31 March 2020

1 reference

Discrimination between methicillin-resistant and methicillin-susceptible Staphylococcus aureus using pyrolysis mass spectrometry and artificial neural networks.

31 March 2020

1 reference

Rapid identification of species within the Mycobacterium tuberculosis complex by artificial neural network analysis of pyrolysis mass spectra.

31 March 2020

1 reference

Deconvolution gas chromatography/mass spectrometry of urinary organic acids--potential for pattern recognition and automated identification of metabolic disorders

31 March 2020

1 reference

Characterization of mycobacteria species by HPLC and pattern recognition

31 March 2020

1 reference

Characterization of diet-dependent metabolic serotypes: analytical and biological variability issues in rats

31 March 2020

1 reference

Diffuse reflectance absorbance spectroscopy taking in chemometrics (DRASTIC). A hyperspectral FT-IR-based approach to rapid screening for metabolite overproduction

31 March 2020

1 reference

Development of a model for classification of toxin-induced lesions using1H NMR spectroscopy of urine combined with pattern recognition

31 March 2020

1 reference

The initial pathogenesis of cadmium induced renal toxicity

31 March 2020

1 reference

A metabonomic approach to the investigation of drug-induced phospholipidosis: an NMR spectroscopy and pattern recognition study

31 March 2020

1 reference

Detection ofin vivo biomarkers of phospholipidosis using NMR-based metabonomic approaches

31 March 2020

1 reference

An investigation of tumor 1H nuclear magnetic resonance spectra by the application of chemometric techniques

31 March 2020

1 reference

Pattern recognition analysis of 1H NMR spectra from perchloric acid extracts of human brain tumor biopsies.

31 March 2020

1 reference

Pattern recognition approaches in biomedical and clinical magnetic resonance spectroscopy: a review.

31 March 2020

1 reference

High resolution 1H NMR spectroscopic studies on dynamic biochemical processes in incubated human seminal fluid samples

31 March 2020

1 reference

Metabolic profiling of chronic cadmium exposure in the rat.

31 March 2020

1 reference

Nuclear magnetic resonance spectroscopy: a non-invasive probe of kidney metabolism and function

31 March 2020

1 reference

Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

31 March 2020

1 reference

Induction of 5-oxoprolinuria in the rat following chronic feeding with N -acetyl 4-aminophenol (paracetamol)

31 March 2020

1 reference

Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis).

31 March 2020

1 reference

Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition

31 March 2020

1 reference

Directly coupled high-performance liquid chromatography and nuclear magnetic resonance spectroscopic with chemometric studies on metabolic variation in Sprague--Dawley rats

31 March 2020

1 reference

beta-Ureidopropionase deficiency: a novel inborn error of metabolism discovered using NMR spectroscopy on urine

31 March 2020

1 reference

In vivo and in vitro NMR spectroscopy reveal a putative novel inborn error involving polyol metabolism

31 March 2020

1 reference

Proton NMR spectroscopic analysis of multiple acyl-CoA dehydrogenase deficiency--capacity of the choline oxidation pathway for methylation in vivo

31 March 2020

1 reference

Uroscopy in the 21st century: high-field NMR spectroscopy.

31 March 2020

1 reference

Analysis of fetal and neonatal urine using proton nuclear magnetic resonance spectroscopy.

31 March 2020

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Automatic data reduction and pattern recognition methods for analysis of 1H nuclear magnetic resonance spectra of human urine from normal and pathological states.

31 March 2020

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Correlation between protein and mRNA abundance in yeast

31 March 2020

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An integrated proteomic approach to studying glomerular nephrotoxicity

31 March 2020

1 reference

High resolution 1H n.m.r. studies of vertebrate blood and plasma

31 March 2020

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Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects

31 March 2020

1 reference

A study of the nephrotoxicity of three cephalosporins in rabbits using 1H NMR spectroscopy

31 March 2020

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High resolution proton magnetic resonance spectroscopy of biological fluids

31 March 2020

1 reference

Proton MRS of human prostatic fluid: Correlations between citrate, spermine, andmyo-inositol levels and changes with disease

31 March 2020

1 reference

Pattern recognition methods and applications in biomedical magnetic resonance

31 March 2020

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NMR spectroscopy of human post mortem cerebrospinal fluid: distinction of Alzheimer's disease from control using pattern recognition and statistics.

31 March 2020

1 reference

750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma

31 March 2020

1 reference

Measurement of biomolecular diffusion coefficients in blood plasma using two-dimensional 1H-1H diffusion-edited total-correlation NMR spectroscopy.

31 March 2020

1 reference

Combined HPLC, NMR Spectroscopy, and Ion-Trap Mass Spectrometry with Application to the Detection and Characterization of Xenobiotic and Endogenous Metabolites in Human Urine

31 March 2020

1 reference

Enhanced resolution of proton NMR spectra of malignant lymph nodes using magic-angle spinning

31 March 2020

1 reference

Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy

31 March 2020

1 reference

High-resolution magic angle spinning 1H NMR spectroscopic studies on intact rat renal cortex and medulla

31 March 2020

1 reference

High-resolution magic angle spinning (1)H NMR spectroscopy of intact liver and kidney: optimization of sample preparation procedures and biochemical stability of tissue during spectral acquisition

31 March 2020

1 reference

High-resolution (1)H and (1)H-(13)C magic angle spinning NMR spectroscopy of rat liver

31 March 2020

1 reference

Gradient, high-resolution, magic-angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue

31 March 2020

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The biochemical profile of rat testicular tissue as measured by magic angle spinning 1H NMR spectroscopy.

31 March 2020

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Metabonomic investigations into hydrazine toxicity in the rat.

31 March 2020

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High-resolution (1)H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue

31 March 2020

1 reference

NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach

31 March 2020

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Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes

31 March 2020

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Pattern recognition used to investigate multivariate data in analytical chemistry

31 March 2020

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31 March 2020

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7 January 2021

inferred from DOI database lookup

Impact of ethanol stress on components of the allantoic fluid of the chicken embryo

1 reference

7 January 2021

inferred from DOI database lookup

Effect of slow growth on metabolism of Escherichia coli, as revealed by global metabolite pool ("metabolome") analysis

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NRD728

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release_abin3dvktvaihexyhipqrxmnye

31 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/abin3dvktvaihexyhipqrxmnye

24 November 2022

mapped directly with Wikidata item

1 reference