(Q34135631)

31 July 2017

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title

Phosphatidylinositol 3-kinases in tumor progression (English)

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31 July 2017

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D Roymans

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31 July 2017

H Slegers

series ordinal

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31 July 2017

language of work or name

English

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publication date

1 February 2001

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31 July 2017

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31 July 2017

volume

268

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31 July 2017

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31 July 2017

page(s)

487-498

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Phosphatidylinositol 3-kinase

31 July 2017

cites work

1 reference

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

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The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

21 January 2018

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Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

21 January 2018

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Signalling through the lipid products of phosphoinositide-3-OH kinase

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21 January 2018

Phosphoinositide kinases

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Phosphoinositide 3-kinases: a conserved family of signal transducers

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Signalling through phosphoinositide 3-kinases: the lipids take centre stage

21 January 2018

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Vesicular transport. Sticky fingers grab a lipid

21 January 2018

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FYVE fingers bind PtdIns(3)P

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A functional PtdIns(3)P-binding motif

21 January 2018

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A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

21 January 2018

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Phosphoinositide 3-Kinase Binds Constitutively to / -Tubulin and Binds to -Tubulin in Response to Insulin

21 January 2018

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Phosphatidylinositol 3-kinase binds to alpha-actinin through the p85 subunit

21 January 2018

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The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors

21 January 2018

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Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation

21 January 2018

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Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

21 January 2018

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

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Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae

21 January 2018

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

21 January 2018

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Phosphatidylinositol kinase activity associates with viral p60src protein

21 January 2018

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Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

21 January 2018

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Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

21 January 2018

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

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PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

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Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma

21 January 2018

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Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

21 January 2018

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

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Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

21 January 2018

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The multiple roles of PTEN in tumor suppression

21 January 2018

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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

21 January 2018

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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

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PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

21 January 2018

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Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

21 January 2018

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

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p70 S6 kinase: an enigma with variations

21 January 2018

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

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Actin-binding protein requirement for cortical stability and efficient locomotion

21 January 2018

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Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

21 January 2018

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Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

21 January 2018

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

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Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells

21 January 2018

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Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

21 January 2018

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Molecular interactions in cell adhesion complexes

21 January 2018

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Regulating integrin-mediated adhesion: one more function for PI 3-kinase?

21 January 2018

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

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c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase

21 January 2018

1 reference

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Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength

21 January 2018

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The integrin alpha 6 beta 4 is a laminin receptor

21 January 2018

1 reference

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Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

The role of local actin instability in axon formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Identification of a putative target for Rho as the serine-threonine kinase protein kinase N

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Disease mechanism: unravelling Wiskott-Aldrich syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

PIP2 and PIP3: complex roles at the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Epidemiology of brain tumors: the national survey of intracranial neoplasms

21 January 2018

1 reference

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Role of glial filaments in cells and tumors of glial origin: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Phosphatidylinositol 3-kinase activity is required for the expression of glial fibrillary acidic protein upon cAMP-dependent induction of differentiation in rat C6 glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

1 reference

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The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

PTEN gene and integrin signaling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

Molecular switches in metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01936.X

10.1046/J.1432-1327.2001.01936.X

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference