(Q34199556)

31 July 2017

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title

The Hedgehog signalling pathway and cancer (English)

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31 July 2017

Saldanha G

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31 July 2017

publication date

1 April 2001

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31 July 2017

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31 July 2017

volume

193

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31 July 2017

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31 July 2017

page(s)

427-432

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Developmental Genes and Cancer: Role of Patched in Basal Cell Carcinoma of the Skin

31 July 2017

cites work

1 reference

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Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 January 2018

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

1 reference

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Mutations affecting segment number and polarity in Drosophila

21 January 2018

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Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog

21 January 2018

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A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities

21 January 2018

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The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

21 January 2018

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A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

21 January 2018

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The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

21 January 2018

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Biochemical evidence that patched is the Hedgehog receptor

21 January 2018

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Characterization of two patched receptors for the vertebrate hedgehog protein family

21 January 2018

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Activating Smoothened mutations in sporadic basal-cell carcinoma

21 January 2018

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Sonic hedgehog signaling by the patched-smoothened receptor complex

21 January 2018

1 reference

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Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

21 January 2018

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Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

21 January 2018

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The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs.

21 January 2018

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Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

21 January 2018

1 reference

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Regulation of patched by sonic hedgehog in the developing neural tube

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer.

21 January 2018

1 reference

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Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein

21 January 2018

1 reference

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The world according to hedgehog

21 January 2018

1 reference

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Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5.

21 January 2018

1 reference

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Developmental pathways: Sonic hedgehog-Patched-GLI

21 January 2018

1 reference

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Identification of an amplified, highly expressed gene in a human glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Relationship between gene amplification and chromosomal deviations in malignant human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Bone morphogenetic proteins in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling

21 January 2018

1 reference

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Mutation and cancer: statistical study of retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

De novo mutations of the Patched gene in nevoid basal cell carcinoma syndrome help to define the clinical phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Sporadic trichoepithelioma demonstrates deletions at 9q22.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Characterisation of human patched germ line mutations in naevoid basal cell carcinoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

PTCH gene mutations in odontogenic keratocysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

PTCH gene mutations in invasive transitional cell carcinoma of the bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

A frequent activated smoothened mutation in sporadic basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

No evidence for the H133Y mutation in SONIC HEDGEHOG in a collection of common tumour types

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Basal cell carcinomas in mice overexpressing sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Signal transduction by the Wnt family of ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

WNTs modulate cell fate and behavior during vertebrate development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Cadherin and catenin biology represent a global mechanism for epithelial cancer progression

21 January 2018

1 reference

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The interactions of APC, E-cadherin and beta-catenin in tumour development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Identification of c-MYC as a target of the APC pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

21 January 2018

1 reference

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The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

21 January 2018

1 reference

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The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors

21 January 2018

1 reference

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Mutational analysis of beta-catenin gene in Japanese ovarian carcinomas: frequent mutations in endometrioid carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals

21 January 2018

1 reference

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Stabilization of beta-catenin by genetic defects in melanoma cell lines

21 January 2018

1 reference

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Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma

21 January 2018

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Expression of beta-catenin, a key mediator of the WNT signaling pathway, in basal cell carcinoma

21 January 2018

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Sonic hedgehog opposes epithelial cell cycle arrest

21 January 2018

1 reference

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Why classify basal cell carcinomas?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

E-cadherin expression in basal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Differential patterns of placental and epithelial cadherin expression in basal cell carcinoma and in the epidermis overlying tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Tumor suppressor activity of the TGF-beta pathway in human cancers

21 January 2018

1 reference

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Genetic events and the role of TGF beta in epithelial tumour progression

21 January 2018

1 reference

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Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

A novel sensitive method to detect frameshift mutations in exonic repeat sequences of cancer-related genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Adaptive antioxidant response of manganese-superoxide dismutase following repetitive UVA irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Mechanism and Function of Signaling by the TGFβ Superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

beta-catenin mutation and expression analysis in ovarian cancer: exon 3 mutations and nuclear translocation in 16% of endometrioid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Nuclear localization of beta-catenin in normal and carcinogenic endometrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

Influence of fibroblasts on the invasion and migration of highly or weakly metastatic B16 melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH815%3E3.0.CO%3B2-N

10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference