(Q34187808)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671667%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

review article

1 reference

title

Senescence, apoptosis and therapy--cutting the lifelines of cancer (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671667%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671667%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Clemens A Schmitt

1 reference

31 July 2017

language of work or name

English

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publication date

1 April 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671667%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

published in

Nature Reviews Cancer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671667%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

volume

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671667%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671667%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

page(s)

286-295

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671667%20AND%20SRC:MED&resulttype=core&format=json

Cancer. p53, guardian of the genome

2 November 2019

cites work

1 reference

p53, the cellular gatekeeper for growth and division

31 March 2020

1 reference

Dissecting p53 tumor suppressor functions in vivo

31 March 2020

1 reference

Extension of life-span by introduction of telomerase into normal human cells

31 March 2020

1 reference

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

31 March 2020

1 reference

Creation of human tumour cells with defined genetic elements

31 March 2020

1 reference

Transformation of normal human cells in the absence of telomerase activation.

31 March 2020

1 reference

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

31 March 2020

1 reference

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

31 March 2020

1 reference

CD30/TNF receptor-associated factor interaction: NF-kappa B activation and binding specificity

31 March 2020

1 reference

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

31 March 2020

1 reference

Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation

31 March 2020

1 reference

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

31 March 2020

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

1 reference

Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori

31 March 2020

1 reference

Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection

31 March 2020

1 reference

Essential role for oncogenic Ras in tumour maintenance

31 March 2020

1 reference

Reversible tumorigenesis by MYC in hematopoietic lineages

31 March 2020

1 reference

Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

31 March 2020

1 reference

Sustained loss of a neoplastic phenotype by brief inactivation of MYC

31 March 2020

1 reference

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

31 March 2020

1 reference

Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types

31 March 2020

1 reference

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

31 March 2020

1 reference

Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

31 March 2020

1 reference

Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

31 March 2020

1 reference

Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

31 March 2020

1 reference

T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication

31 March 2020

1 reference

Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas

31 March 2020

1 reference

Overcoming cellular senescence in human cancer pathogenesis

31 March 2020

1 reference

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

31 March 2020

1 reference

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

31 March 2020

1 reference

Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

31 March 2020

1 reference

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

31 March 2020

1 reference

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

31 March 2020

1 reference

Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest

31 March 2020

1 reference

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

31 March 2020

1 reference

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

31 March 2020

1 reference

Identification of CDK4 as a target of c-MYC.

31 March 2020

1 reference

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

31 March 2020

1 reference

Initiating oncogenic event determines gene-expression patterns of human breast cancer models

31 March 2020

1 reference

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

31 March 2020

1 reference

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

1 reference

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

31 March 2020

1 reference

Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

31 March 2020

1 reference

Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence

31 March 2020

1 reference

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

31 March 2020

1 reference

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

31 March 2020

1 reference

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

31 March 2020

1 reference

Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts

31 March 2020

1 reference

CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

31 March 2020

1 reference

Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence

31 March 2020

1 reference

The INK4a/ARF network in tumour suppression

31 March 2020

1 reference

The RB and p53 pathways in cancer

31 March 2020

1 reference

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

31 March 2020

1 reference

p19ARF links the tumour suppressor p53 to Ras

31 March 2020

1 reference

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence

31 March 2020

1 reference

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

31 March 2020

1 reference

Mediation of c-Myc-induced apoptosis by p53.

31 March 2020

1 reference

Induction of apoptosis in fibroblasts by c-myc protein

31 March 2020

1 reference

E2F activity is essential for survival of Myc-overexpressing human cancer cells

31 March 2020

1 reference

Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis

31 March 2020

1 reference

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

31 March 2020

1 reference

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

31 March 2020

1 reference

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

1 reference

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

31 March 2020

1 reference

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

31 March 2020

1 reference

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

31 March 2020

1 reference

Dual inactivation of RB and p53 pathways in RAS-induced melanomas

31 March 2020

1 reference

p53-independent functions of the p19(ARF) tumor suppressor

31 March 2020

1 reference

Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: a report of 48 cases

31 March 2020

1 reference

p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

31 March 2020

1 reference

p53 genetic abnormalities and myc activation in human lung carcinoma

31 March 2020

1 reference

Identification of Myc-mediated death response pathways by microarray analysis

31 March 2020

1 reference

The role of chromosomal instability in tumor initiation

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

31 March 2020

1 reference

p53 status and the efficacy of cancer therapy in vivo

31 March 2020

1 reference

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

31 March 2020

1 reference

Hemizygous p16(INK4A) deletion in pediatric acute lymphoblastic leukemia predicts independent risk of relapse

31 March 2020

1 reference

Senescent human neutrophil binding to thrombospondin (TSP): evidence for a TSP-independent pathway of phagocytosis by macrophages

31 March 2020

1 reference

The tumor-infiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells.

31 March 2020

1 reference

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

31 March 2020

1 reference

Cell-cycle arrest versus cell death in cancer therapy

31 March 2020

1 reference

Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4.

31 March 2020

1 reference

Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study

31 March 2020

1 reference

The serial cultivation of human diploid cell strains

31 March 2020

1 reference

Telomeres shorten during ageing of human fibroblasts

31 March 2020

1 reference

Cellular senescence: mitotic clock or culture shock?

31 March 2020

1 reference

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

31 March 2020

1 reference

Microarray analysis of replicative senescence

31 March 2020

1 reference

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

31 March 2020

1 reference

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

31 March 2020

1 reference

Clusterin/apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblasts

31 March 2020

1 reference

Senescence-dependent regulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells

31 March 2020

1 reference

Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

31 March 2020

1 reference

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent

31 March 2020

1 reference

Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence

31 March 2020

1 reference

Massive telomere loss is an early event of DNA damage-induced apoptosis

31 March 2020

1 reference