(Q34180688)

31 July 2017

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title

Tamoxifen: a most unlikely pioneering medicine (English)

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31 July 2017

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V Craig Jordan

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31 July 2017

publication date

1 March 2003

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Nature Reviews Drug Discovery

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

205-213

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A new derivative of triphenylethylene: effect on implantation and mode of action in rats

31 July 2017

cites work

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A New Anti-oestrogenic Agent in Late Breast Cancer: An Early Clinical Appraisal of ICI46474

21 January 2018

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Anti-oestrogen Therapy for Breast Cancer: A Trial of Tamoxifen at Two Dose Levels

21 January 2018

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Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer

21 January 2018

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Gonadotrophin inhibiting and anti-fecundity effects of chloramiphene

21 January 2018

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Antioestrogens in treatment of breast cancer: value of nafoxidine in 52 advanced cases.

21 January 2018

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Role of Oestrogen in Spontaneous Ovulation demonstrated by Use of an Antagonist of Oestrogen, ICI 46,474

21 January 2018

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Effects of an antioestrogen on the corpus luteum of rabbits and rats

21 January 2018

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Role of Estrogens in Spontaneous Ovulation: Evidence for Positive Feedback in Hamsters

21 January 2018

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The development of tamoxifen for breast cancer therapy: a tribute to the late Arthur L. Walpole

21 January 2018

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21 January 2018

Antioestrogens. A review

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Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.

21 January 2018

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Effect of some triphenylethylenes on oestradiol binding in vitro to macromolecules from uterus and anterior pituitary

21 January 2018

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A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity

21 January 2018

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Evidence for the metabolic activation of non-steroidal antioestrogens: a study of structure-activity relationships

21 January 2018

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Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor

21 January 2018

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Tamoxifen as an anti-tumour agent: effect on oestrogen binding

21 January 2018

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Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group

21 January 2018

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Alternative mechanisms of action of anti-oestrogens

21 January 2018

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Oestrogen-responsive human breast cancer in long term tissue culture

21 January 2018

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Improved survival among patients treated with adjuvant tamoxifen after mastectomy for early breast cancer

21 January 2018

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Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial

21 January 2018

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Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer

21 January 2018

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Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

21 January 2018

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First results from the International Breast Cancer Intervention Study (IBIS-I): a randomised prevention trial

21 January 2018

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A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer

21 January 2018

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Adjuvant tamoxifen in early breast cancer: occurrence of new primary cancers

21 January 2018

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Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14.

21 January 2018

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The role of induction therapy and surgery for stage IIIA lung cancer

21 January 2018

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Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators

21 January 2018

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The Effect of Raloxifene on Risk of Breast Cancer in Postmenopausal Women

21 January 2018

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Phase II Evaluation of Lyl56758 in Metastatic Breast Cancer

21 January 2018

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Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial

21 January 2018

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Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial

21 January 2018

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Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial

21 January 2018

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Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment

21 January 2018

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Contrasting Endocrine Activities of cis and trans Isomers in a Series of Substituted Triphenylethylenes

21 January 2018

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Preparation and Identification of cis and trans Isomers of a Substituted Triarylethylene

21 January 2018

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Mode of action of I.C.I. 46,474 in preventing implantation in rats

21 January 2018

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A non-steroidal estrogen antiagonist 1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol

31 March 2020

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Nafoxidine--an antiestrogen for the treatment of breast cancer

31 March 2020

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Induction of ovulation with MRL/41. Preliminary report

31 March 2020

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31 March 2020

Induction of ovulation

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Clomiphene citrate: experience with 217 patients. Variation in response and unusual reactions

31 March 2020

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The effects of triparanol (MER-29) in subjects with and without coronary artery disease

31 March 2020

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Cataracts in Patients Treated with Triparanol

31 March 2020

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Influence of Synthetic Oestrogens on Advanced Malignant Disease

31 March 2020

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Synthetic oestrogens in mammary cancer

31 March 2020

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Role of Estrogens in Ovulation: A Study Using the Estrogen-Antagonist, I.C.I. 46,474

31 March 2020

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New synthetic agent for the induction of ovulation: preliminary trials in women

31 March 2020

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Treatment of menometrorrhagia with an anti-oestrogen

31 March 2020

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Substituted Aminoalkoxytriarylhaloethylenes

31 March 2020

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Stereochemistry of geometric isomers of clomiphene: A Correction of the Literature and a Reexamination of Structure‐Activity Relationships

31 March 2020

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31 March 2020

Postcoital contraception

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The effect of synthetic anti-oestrogens on the growth and biochemistry of rat mammary tumours

31 March 2020

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Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata

31 March 2020

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Tamoxifen as an anti-tumour agent: oestrogen binding as a predictive test for tumour response

31 March 2020

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Tamoxifen (antiestrogen) therapy in advanced breast cancer

31 March 2020

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Controlled trial of tamoxifen as a single adjuvant agent in the management of early breast cancer. 'Nolvadex' Adjuvant Trial Organisation

31 March 2020

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Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model

31 March 2020

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Human breast cancer in the athymic nude mouse: cytostatic effects of long-term antiestrogen therapy

31 March 2020

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Effects of anti-estrogens on bone in castrated and intact female rats

31 March 2020

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Effects of tamoxifen on cardiovascular risk factors in postmenopausal women

31 March 2020

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Suppression of mouse mammary tumorigenesis by long-term tamoxifen therapy

31 March 2020

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Tamoxifen and contralateral breast cancer

31 March 2020

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Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial

31 March 2020

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Projecting individualized probabilities of developing breast cancer for white females who are being examined annually

31 March 2020

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What if tamoxifen (ICI 46,474) had been found to produce rat liver tumors in 1973? A personal perspective

31 March 2020

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31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1031

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31 July 2017

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