(Q34180645)

31 July 2017

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title

HIF-1 and mechanisms of hypoxia sensing (English)

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31 July 2017

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G L Semenza

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31 July 2017

publication date

1 April 2001

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Current Opinion in Cell Biology

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

167-171

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The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions

31 July 2017

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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

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7 January 2021

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7 January 2021

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7 January 2021

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

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7 January 2021

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7 January 2021

O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase

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7 January 2021

NADPH oxidase is an O2 sensor in airway chemoreceptors: evidence from K+ current modulation in wild-type and oxidase-deficient mice

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7 January 2021

Mice lacking in gp91 phox subunit of NAD(P)H oxidase showed glomus cell [Ca(2+)](i) and respiratory responses to hypoxia

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7 January 2021

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7 January 2021

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Identifiers

DOI

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31 July 2017

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