(Q34172256)

31 July 2017

title

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases (English)

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31 July 2017

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Davidson HW

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31 July 2017

Rhodes CJ

series ordinal

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31 July 2017

Hutton JC

series ordinal

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31 July 2017

language of work or name

English

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publication date

1 May 1988

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31 July 2017

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31 July 2017

volume

333

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31 July 2017

issue

6168

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31 July 2017

page(s)

93-96

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Post-translational proteolysis in polypeptide hormone biosynthesis

31 July 2017

cites work

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7 January 2021

Proteolysis in Neuropeptide Processing and Other Neural Functions

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7 January 2021

Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules

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7 January 2021

Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10)

1 reference

7 January 2021

The internal pH and membrane potential of the insulin-secretory granule

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7 January 2021

Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate

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7 January 2021

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

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7 January 2021

The electron microscopic localization of cations to pancreatic islets of langerhans and their possible role in insulin secretion

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7 January 2021

The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing

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7 January 2021

Biochemical and clinical implications of proinsulin conversion intermediates

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7 January 2021

The insulin factory: a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited

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7 January 2021

Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules

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7 January 2021

Ca-activated ATPase activity in subcellular fractions of mouse pancreatic islets

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7 January 2021

Differences in the nature of the interaction of insulin and proinsulin with zinc

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7 January 2021

Calcium and pancreatic β-cell function6. glucose and intracellular 45Ca distribution

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7 January 2021

Biosynthesis of betagranin in pancreatic beta-cells. Identification of a chromogranin A-like precursor and its parallel processing with proinsulin.

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7 January 2021

Biosynthesis of insulin secretory granule membrane proteins. Control by glucose.

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7 January 2021

Role of zinc and calcium in the formation and storage of insulin in the pancreatic ?-cell

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7 January 2021

Direct effects of glucose on proinsulin synthesis and processing during desensitization

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7 January 2021

Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway

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7 January 2021

Use of a synthetic peptide antigen to generate antisera reactive with a proteolytic processing site in native human proinsulin: demonstration of cleavage within clathrin-coated (pro)secretory vesicles

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7 January 2021

Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation

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7 January 2021

Secretion and processing of insulin precursors in yeast

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7 January 2021

Calcium-dependent KEX2-like protease found in hepatic secretory vesicles converts proalbumin to albumin.

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7 January 2021

Concentration of MgATP2- and other ions in solution. Calculation of the true concentrations of species present in mixtures of associating ions

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7 January 2021

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

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7 January 2021

Identifiers

DOI

10.1038/333093A0

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Dimensions Publication ID

31 July 2017

1025356928

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