(Q34153014)

31 July 2017

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title

The role of mutant p53 in human cancer (English)

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31 July 2017

Amanda M Goh

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31 July 2017

Cynthia R Coffill

series ordinal

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31 July 2017

David P Lane

series ordinal

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31 July 2017

publication date

25 October 2010

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31 July 2017

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31 July 2017

volume

223

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31 July 2017

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31 July 2017

page(s)

116-126

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The first 30 years of p53: growing ever more complex

31 July 2017

cites work

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

21 January 2018

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Rescuing the function of mutant p53.

21 January 2018

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Awakening guardian angels: drugging the p53 pathway

21 January 2018

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

21 January 2018

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The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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Mdmx as an essential regulator of p53 activity

21 January 2018

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HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

21 January 2018

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Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

21 January 2018

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Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

21 January 2018

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p53, a transformation-related cellular-encoded protein, can be used as a biochemical marker for the detection of primary mouse tumor cells

21 January 2018

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A candidate precursor to serous carcinoma that originates in the distal fallopian tube.

21 January 2018

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Presence of dominant negative mutation of TP53 is a risk of early recurrence in oral cancer.

21 January 2018

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Frequent clones of p53-mutated keratinocytes in normal human skin

21 January 2018

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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

21 January 2018

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High metastatic potential in mice inheriting a targeted p53 missense mutation

21 January 2018

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

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The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

21 January 2018

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The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation

21 January 2018

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

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Ubiquitination and degradation of mutant p53.

21 January 2018

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Detection of the p53 response in zebrafish embryos using new monoclonal antibodies

21 January 2018

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Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein

21 January 2018

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TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

21 January 2018

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Regulation of DNA binding of p53 by its C-terminal domain

21 January 2018

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Oncogenic forms of p53 inhibit p53-regulated gene expression

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

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p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines

21 January 2018

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Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development

21 January 2018

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

21 January 2018

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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

21 January 2018

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How many mutant p53 molecules are needed to inactivate a tetramer?

21 January 2018

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The R246S hot-spot p53 mutant exerts dominant-negative effects in embryonic stem cells in vitro and in vivo.

21 January 2018

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p53 isoforms can regulate p53 transcriptional activity.

21 January 2018

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Gain of function mutations in p53.

21 January 2018

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An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations

21 January 2018

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An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

21 January 2018

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p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

21 January 2018

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Mutant p53 drives invasion by promoting integrin recycling

21 January 2018

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Expression of a mutant p53 results in an age-related demographic shift in spontaneous lung tumor formation in transgenic mice.

21 January 2018

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Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis

21 January 2018

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Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

21 January 2018

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TP53 mutations and breast cancer prognosis: particularly poor survival rates for cases with mutations in the zinc-binding domains.

21 January 2018

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Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?

21 January 2018

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p63 and p73 in human cancer: defining the network

21 January 2018

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The p53 family in differentiation and tumorigenesis.

21 January 2018

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p63 is a p53 homologue required for limb and epidermal morphogenesis

21 January 2018

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

21 January 2018

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

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TAp63 induces senescence and suppresses tumorigenesis in vivo

21 January 2018

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TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

21 January 2018

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Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

21 January 2018

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

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Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

21 January 2018

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p73 can suppress the proliferation of cells that express mutant p53.

21 January 2018

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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

21 January 2018

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p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

21 January 2018

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Mutant p53 gain-of-function in cancer

21 January 2018

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Mutant p53 protein expression interferes with p53-independent apoptotic pathways

21 January 2018

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p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

21 January 2018

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Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo

21 January 2018

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TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria

21 January 2018

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TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma.

21 January 2018

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Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73

21 January 2018

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Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

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Increased expression of mutant forms of p53 oncogene in primary lung cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.2784

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31 July 2017

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