(Q34074186)

30 July 2017

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title

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review (English)

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30 July 2017

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30 July 2017

Nixon RA

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30 July 2017

Cataldo AM

series ordinal

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30 July 2017

publication date

1 October 2000

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30 July 2017

published in

Neurochemical Research

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30 July 2017

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30 July 2017

issue

9-10

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30 July 2017

page(s)

1161-1172

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Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants

30 July 2017

cites work

1 reference

12 December 2020

Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'.

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12 December 2020

The endosomal-lysosomal system of neurons: new roles

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12 December 2020

Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus.

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12 December 2020

Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction--single strand conformational polymorphism analysis and possible consequences in cancer cells

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12 December 2020

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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12 December 2020

Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.

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12 December 2020

Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer’s Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis

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12 December 2020

46-kDa mannose 6-phosphate-specific receptor: biosynthesis, processing, subcellular location and topology.

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12 December 2020

Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent

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12 December 2020

A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier

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12 December 2020

The proto-oncogene Bcl-2 and its role in regulating apoptosis

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12 December 2020

Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting

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12 December 2020

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

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12 December 2020

Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes

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12 December 2020

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

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12 December 2020

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

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12 December 2020

Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

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12 December 2020

On the metabolism of apolipoprotein E and the Alzheimer diseases

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12 December 2020

rab5 controls early endosome fusion in vitro

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12 December 2020

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

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12 December 2020

Cell and molecular neurobiology of presenilins: A role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?

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12 December 2020

The Bax alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia

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12 December 2020

Presenilins and Alzheimer disease

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12 December 2020

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

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12 December 2020

Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

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12 December 2020

Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome

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12 December 2020

Cell death induced by peroxidized low-density lipoprotein: endopepsis

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12 December 2020

Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation

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12 December 2020

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells

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12 December 2020

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

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12 December 2020

Prevalence of dementia of Alzheimer type and apolipoprotein E phenotypes in aged patients with Down's syndrome

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12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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12 December 2020

A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease.

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12 December 2020

Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.

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12 December 2020

A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.

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12 December 2020

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

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12 December 2020

Heterologous transmembrane and cytoplasmic domains direct functional chimeric influenza virus hemagglutinins into the endocytic pathway

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12 December 2020

Molecular aspects of the endocytic pathway

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12 December 2020

Differential localization of cysteine protease inhibitors and a target cysteine protease, cathepsin B, by immuno-confocal microscopy

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12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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12 December 2020

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

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12 December 2020

Apolipoprotein E and the CNS response to injury.

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12 December 2020

Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that int

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12 December 2020

APOE-491 promoter polymorphism is a risk factor for late-onset Alzheimer's disease.

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12 December 2020

Activation of caspase-3 and apoptosis in cerebellar granule cells

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12 December 2020

Protective effect of 17 beta-estradiol against the cytotoxicity of minimally oxidized LDL to cultured bovine aortic endothelial cells

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12 December 2020

The human entorhinal cortex: normal morphology and lamina-specific pathology in various diseases

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12 December 2020

Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease

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12 December 2020

Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's disease

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12 December 2020

Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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12 December 2020

Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?

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12 December 2020

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

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12 December 2020

Oxidant-induced apoptosis: a consequence of lethal lysosomal leak?

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12 December 2020

Association of interleukin-1 gene polymorphisms with Alzheimer's disease

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12 December 2020

ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families

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12 December 2020

Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism.

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12 December 2020

Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling

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12 December 2020

The lysosomal system in neuronal cell death: a review

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12 December 2020

The synchronization between brain areas under motor inhibition process in humans estimated by event-related EEG coherence

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12 December 2020

Relative efficacies of amyloid beta peptide (A beta) binding proteins in A beta aggregation.

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12 December 2020

Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.

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12 December 2020

The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis

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12 December 2020

Candidate .gamma.-Secretases in the Generation of the Carboxyl Terminus of the Alzheimer's Disease .beta.A4 Amyloid: Possible Involvement of Cathepsin D

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12 December 2020

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

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12 December 2020

Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

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12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases

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12 December 2020

Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases

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12 December 2020

Photo-Oxidative Disruption of Lysosomal Membranes Causes Apoptosis of Cultured Human Fibroblasts

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12 December 2020

Seeding of A beta fibril formation is inhibited by all three isotypes of apolipoprotein E.

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12 December 2020

The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type

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12 December 2020

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi

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12 December 2020

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

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12 December 2020

The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway

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12 December 2020

Apolipoprotein E alleles as risk factors in Alzheimer's disease

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12 December 2020

Isoform-Specific Effect of Apolipoprotein E on Cell Survival and β-Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures

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12 December 2020

Normal and abnormal biology of the beta-amyloid precursor protein

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12 December 2020

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

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12 December 2020

Processing of the Pre‐β‐amyloid Protein by Cathepsin d is Enhanced by a Familial Alzheimer's Disease Mutation

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12 December 2020

Dementia of the Alzheimer type. Clinical genetics, natural history, and associated conditions

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12 December 2020

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

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12 December 2020

Cathepsin D gene exon 2 polymorphism and sporadic Alzheimer's disease.

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12 December 2020

Ethanol-impaired hepatic protein trafficking: concepts from the asialoglycoprotein receptor system

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12 December 2020

The gene defects responsible for familial Alzheimer's disease

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12 December 2020

Tau protein and the neurofibrillary pathology of Alzheimer's disease

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12 December 2020

Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome

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12 December 2020

Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes

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12 December 2020

Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

Cytochrome c in the apoptotic and antioxidant cascades

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12 December 2020

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha

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12 December 2020

Cathepsin D displays in vitro beta-secretase-like specificity.

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12 December 2020

Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway

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12 December 2020

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

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12 December 2020

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

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12 December 2020

Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation

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12 December 2020

Bcl-2 family proteins: strategies for overcoming chemoresistance in cancer

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12 December 2020

Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation

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12 December 2020

Lysosomal dysfunction reduces brain-derived neurotrophic factor expression

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12 December 2020

Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis

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12 December 2020

Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease.

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12 December 2020

Association between bleomycin hydrolase and Alzheimer's disease in caucasians

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12 December 2020

Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress

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12 December 2020

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

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12 December 2020

Apolipoprotein E and cognitive change in an elderly population.

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12 December 2020

Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Apolipoprotein E Binds to and Potentiates the Biological Activity of Ciliary Neurotrophic Factor

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12 December 2020

Genetic and molecular advances in Alzheimer's disease

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12 December 2020

Genetic risk factors in Japanese Alzheimer's disease patients: alpha1-ACT, VLDLR, and ApoE.

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12 December 2020

An endothelial receptor for oxidized low-density lipoprotein

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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12 December 2020

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

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12 December 2020

Late Compartments of Amyloid Precursor Protein Transport in SY5Y Cells Are Involved in β-Amyloid Secretion

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12 December 2020

Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes

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12 December 2020

Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease

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12 December 2020

Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.

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12 December 2020

Antioxidant protection of LDL by physiologic concentrations of estrogens is specific for 17-beta-estradiol.

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12 December 2020

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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12 December 2020

Identification of the lrp gene in Bradyrhizobium japonicum and its role in regulation of delta-aminolevulinic acid uptake

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12 December 2020

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

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12 December 2020

APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome.

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12 December 2020

Uptake of Oxidized LDL by Macrophages Results in Partial Lysosomal Enzyme Inactivation and Relocation

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12 December 2020

Molecular mechanisms of endocytosis

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12 December 2020

Protease activities in normal and schizophrenic human prefrontal cortex and white matter

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12 December 2020

Caspases: the executioners of apoptosis

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12 December 2020

Identifiers

DOI

10.1023/A:1007675508413

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Dimensions Publication ID

30 July 2017

1041017177

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