(Q34055749)

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In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20538611%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation (English)

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5 February 2020

electrophysiology

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10

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5 February 2020

Theodore R Cummins

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Theodore R Cummins

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5 February 2020

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Yuying Wang

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5 February 2020

Joel M Brittain

2

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5 February 2020

Brian W Jarecki

3

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5 February 2020

Ki Duk Park

4

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5 February 2020

Sarah M Wilson

5

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5 February 2020

Bo Wang

6

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5 February 2020

Rachel Hale

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5 February 2020

Samy O Meroueh

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5 February 2020

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9 June 2010

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5 February 2020

Journal of Biological Chemistry

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5 February 2020

285

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5 February 2020

33

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5 February 2020

25296-25307

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5 February 2020

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2919092/fullTextXML

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Emerging roles of collapsin response mediator proteins (CRMPs) as regulators of voltage-gated calcium channels and synaptic transmission

1 reference

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Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons.

1 reference

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Tubulin polymerization modifies cardiac sodium channel expression and gating

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28 July 2018

Lacosamide: an adjunctive agent for partial-onset seizures and potential therapy for neuropathic pain

1 reference

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28 July 2018

Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors

1 reference

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28 July 2018

An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels

1 reference

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28 July 2018

Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders

1 reference

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28 July 2018

Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit

1 reference

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NS21: re-defined and modified supplement B27 for neuronal cultures

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28 July 2018

Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine

1 reference

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28 July 2018

The CRMP family of proteins and their role in Sema3A signaling

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28 July 2018

Lacosamide: a review of preclinical properties.

1 reference

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28 July 2018

The role of synaptic reorganization in mesial temporal lobe epilepsy

1 reference

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28 July 2018

Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones

1 reference

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28 July 2018

Sodium channel inactivation: molecular determinants and modulation

1 reference

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28 July 2018

Reduction of hippocampal collapsin response mediated protein-2 in patients with mesial temporal lobe epilepsy.

1 reference

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28 July 2018

Molecular diversity of voltage-gated sodium channel alpha subunits expressed in neuronal and non-neuronal excitable cells

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Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

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28 July 2018

The dual effect of membrane potential on sodium conductance in the giant axon of Loligo

1 reference

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28 July 2018

Structural bases for CRMP function in plexin-dependent semaphorin3A signaling

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CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth

1 reference

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28 July 2018

Mechanisms of sodium channel inactivation

1 reference

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28 July 2018

CRMP-2 binds to tubulin heterodimers to promote microtubule assembly

1 reference

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28 July 2018

Nomenclature of voltage-gated sodium channels

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CNS voltage-dependent Na(+) channel expression and distribution in an undifferentiated and differentiated CNS cell line.

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From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

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Changes in the mRNAs encoding subtypes I, II and III sodium channel alpha subunits following kainate-induced seizures in rat brain

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A family of rat CRMP genes is differentially expressed in the nervous system

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1 reference

https://pubmed.ncbi.nlm.nih.gov/20538611

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic analysis of stargazer mutant mouse neuronal proteins involved in absence seizure

1 reference

https://pubmed.ncbi.nlm.nih.gov/20538611

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.128801

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20538611%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20538611%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20538611%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

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