(Q33939098)

30 July 2017

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title

Caco-2 monolayers in experimental and theoretical predictions of drug transport (English)

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30 July 2017

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P Artursson

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30 July 2017

K Palm

series ordinal

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30 July 2017

K Luthman

series ordinal

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30 July 2017

language of work or name

English

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publication date

1 March 2001

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Advanced Drug Delivery Reviews

30 July 2017

published in

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30 July 2017

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30 July 2017

issue

1-3

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30 July 2017

page(s)

27-43

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In vitro systems for studying intestinal drug absorption

30 July 2017

cites work

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pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells

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7 January 2021

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7 January 2021

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

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Differentiated intestinal epithelial cell lines asin vitro models for predicting the intestinal absorption of drugs

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7 January 2021

Estimation of recombinant bovine somatotropin solubility by excluded-volume interaction with polyethylene glycols

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7 January 2021

Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat

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Occludin: a novel integral membrane protein localizing at tight junctions

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7 January 2021

Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport

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7 January 2021

Oral vaccination. Identification of classes of proteins that provoke an immune response upon oral feeding

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7 January 2021

Horseradish peroxidase transport across adult rabbit jejunum in vitro

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7 January 2021

Quantification of protein transcytosis in the human colon carcinoma cell line CaCo-2.

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7 January 2021

Polarity in the transcytotic processing of apical and basal membrane-bound peroxidase-polylysine conjugates in MDCK cells

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7 January 2021

Binding and transport of some bioadhesive plant lectins across Caco-2 cell monolayers

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7 January 2021

Apical-to-basolateral transepithelial transport of human lactoferrin in the intestinal cell line HT-29cl.19A.

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7 January 2021

Intestinal tissue distribution and epithelial transport of the oral immunogen LTB, the B subunit of E. coli heat-labile enterotoxin

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7 January 2021

Convective solvent flow across the skin during iontophoresis

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7 January 2021

In vitro/in vivo models for peptide oral absorption: comparison of Caco-2 cell permeability with rat intestinal absorption of renin inhibitory peptides

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7 January 2021

Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man

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7 January 2021

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

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7 January 2021

Membrane permeability parameters for some amino acids and beta-lactam antibiotics: application of the boundary layer approach.

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7 January 2021

The intestinal unstirred layer: its surface area and effect on active transport kinetics.

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7 January 2021

Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells

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7 January 2021

Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments

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7 January 2021

Characterization of drug transport through tight-junctional pathway in Caco-2 monolayer: comparison with isolated rat jejunum and colon

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7 January 2021

Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic

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7 January 2021

Involvement of the myenteric plexus in the cholera toxin-induced net fluid secretion in the rat small intestine

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7 January 2021

Structural basis for physiological regulation of paracellular pathways in intestinal epithelia

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7 January 2021

Nutrient influences on rat intestinal phenytoin uptake

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7 January 2021

Mechanism by which glucose stimulates the passive absorption of small solutes by the human jejunum in vivo

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7 January 2021

Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat

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7 January 2021

Transepithelial transport properties of peptidomimetic thrombin inhibitors in monolayers of a human intestinal cell line (Caco-2) and their correlation to in vivo data

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7 January 2021

Conditionally immortalized intestinal epithelial cells: novel approach for study of differentiated enterocytes

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7 January 2021

A drug absorption model based on the mucus layer producing human intestinal goblet cell line HT29-H.

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7 January 2021

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7 January 2021

Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice

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7 January 2021

Transport of a large neutral amino acid (phenylalanine) in a human intestinal epithelial cell line: Caco-2.

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7 January 2021

Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2).

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7 January 2021

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans

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7 January 2021

Evidence for an interaction between the beta-blocker pafenolol and bile salts in the intestinal lumen of the rat leading to dose-dependent oral absorption and double peaks in the plasma concentration-time profile

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7 January 2021

Intestinal absorption of a beta-adrenergic blocking agents nadolol. II. Mechanism of the inhibitory effect on the intestinal absorption of nadolol by sodium cholate in rats

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7 January 2021

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7 January 2021

Transepithelial transport and metabolism of thyrotropin-releasing hormone (TRH) in monolayers of a human intestinal cell line (Caco-2): evidence for an active transport component?

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7 January 2021

Caco-2 cells cultured in serum-free medium as a model for the study of enterocytic differentiation in vitro

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7 January 2021

A model of human small intestinal absorptive cells. 1. Transport barrier

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7 January 2021

Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption

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7 January 2021

A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry

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7 January 2021

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

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7 January 2021

The influence of peptide structure on transport across Caco-2 cells

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7 January 2021

A method to determine the ability of drugs to diffuse through the blood-brain barrier

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7 January 2021

Atom/fragment contribution method for estimating octanol-water partition coefficients.

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7 January 2021

Molecular lipophilicity potential, a tool in 3D QSAR: method and applications.

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7 January 2021

The influence of molecular volume and hydrogen-bonding on peptide transport across epithelial membranes

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7 January 2021

Use of a biophysical-kinetic model to understand the roles of protein binding and membrane partitioning on passive diffusion of highly lipophilic molecules across cellular barriers

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7 January 2021

Transcellular permeability of chlorpromazine demonstrating the roles of protein binding and membrane partitioning

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7 January 2021

The absorption of beta-adrenoceptor antagonists in rat in-situ small intestine; the effect of lipophilicity

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7 January 2021

Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa

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7 January 2021

Drug delivery studies in Caco-2 monolayers. Synthesis, hydrolysis, and transport of O-cyclopropane carboxylic acid ester prodrugs of various beta-blocking agents.

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7 January 2021

Molecular Organization of Liquid n-Octanol: An X-ray Diffraction Analysis

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7 January 2021

IAM chromatography: an in vitro screen for predicting drug membrane permeability

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7 January 2021

Immobilized-liposome chromatographic analysis of drug partitioning into lipid bilayers

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7 January 2021

The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability

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7 January 2021

Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides

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7 January 2021

Accessible surface areas as a measure of the thermodynamic parameters of hydration of peptides

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https://api.crossref.org/works/10.1016%2FS0169-409X%2800%2900128-9

7 January 2021

The role of solvent-accessible surface area in determining partition coefficients

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https://api.crossref.org/works/10.1016%2FS0169-409X%2800%2900128-9

7 January 2021

Correlation of drug absorption with molecular surface properties

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https://api.crossref.org/works/10.1016%2FS0169-409X%2800%2900128-9

7 January 2021

On the analytical calculation of van der Waals surfaces and volumes: Some numerical aspects

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7 January 2021

10.1016/S0169-409X(00)00128-9

Identifiers

DOI

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30 July 2017

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