(Q33985888)

30 July 2017

title

Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways (English)

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30 July 2017

0 references

1 reference

Guomei Tang

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30 July 2017

Zhenyu Yue

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30 July 2017

Zsolt Talloczy

1 reference

30 July 2017

Tracy Hagemann

1 reference

30 July 2017

Woosung Cho

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30 July 2017

Albee Messing

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30 July 2017

David L Sulzer

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30 July 2017

James E Goldman

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30 July 2017

publication date

14 February 2008

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30 July 2017

published in

Human Molecular Genetics

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

1540-1555

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How to interpret LC3 immunoblotting

30 July 2017

cites work

1 reference

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Alexander disease-associated glial fibrillary acidic protein mutations in mice induce Rosenthal fiber formation and a white matter stress response.

5 July 2018

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The roles of intracellular protein-degradation pathways in neurodegeneration

5 July 2018

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Induction of autophagy in axonal dystrophy and degeneration

5 July 2018

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Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

5 July 2018

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Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease

5 July 2018

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Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

5 July 2018

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

5 July 2018

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Growing roles for the mTOR pathway

5 July 2018

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HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

5 July 2018

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Role of molecular chaperones in neurodegenerative disorders

5 July 2018

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The coordinate regulation of the p53 and mTOR pathways in cells

5 July 2018

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Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades

5 July 2018

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Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease

5 July 2018

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The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

5 July 2018

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Huntingtin processing in pathogenesis of Huntington disease.

5 July 2018

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Autophagy: molecular mechanisms, physiological functions and relevance in human pathology

5 July 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

5 July 2018

1 reference

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Mechanism of p38 MAP kinase activation in vivo.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

GFAP mutations in Alexander disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Cell hydration controls autophagosome formation in rat liver in a microtubule-dependent way downstream from p38MAPK activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Tor-mediated induction of autophagy via an Apg1 protein kinase complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Formation of GFAP cytoplasmic inclusions in astrocytes and their disaggregation by alphaB-crystallin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Mechanism of activation of protein kinase B by insulin and IGF-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Overexpression and abnormal modification of the stress proteins alpha B-crystallin and HSP27 in Alexander disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

The role of increased proteolysis in the atrophy and arrest of proliferation in serum-deprived fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Isolation of a major protein component of Rosenthal fibers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

In yeast, loss of Hog1 leads to osmosensitivity of autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Involvement of macroautophagy in the dissolution of neuronal inclusions

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Alexander disease: a leukodystrophy caused by a mutation in GFAP.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Autophagy regulates the processing of amino terminal huntingtin fragments

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

A novel cell type-specific role of p38α in the control of autophagy and cell death in colorectal cancer cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902290

Synthesis and turnover of cytoskeletal proteins in cultured astrocytes

29 October 2018

1 reference

12 December 2020

Turnover of glial filaments in mouse spinal cord

1 reference

12 December 2020

Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP

1 reference

12 December 2020

Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDN042

1 reference

30 July 2017

1 reference

30 July 2017

1 reference