(Q33810376)

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Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?

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Europe PubMed Central

PubMed publication ID

29 July 2017

Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats? (English)

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Europe PubMed Central

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29 July 2017

author name string

Miroslav M Savić

1

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Europe PubMed Central

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29 July 2017

Samarpan Majumder

2

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29 July 2017

Shengming Huang

3

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29 July 2017

Rahul V Edwankar

4

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29 July 2017

Roman Furtmüller

5

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29 July 2017

Srdan Joksimović

6

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29 July 2017

Terry Clayton

7

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29 July 2017

Joachim Ramerstorfer

8

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29 July 2017

Marija M Milinković

9

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Europe PubMed Central

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29 July 2017

Bryan L Roth

10

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29 July 2017

Werner Sieghart

11

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29 July 2017

James M Cook

12

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29 July 2017

publication date

13 January 2010

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Europe PubMed Central

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29 July 2017

Progress in Neuro-Psychopharmacology & Biological Psychiatry

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29 July 2017

34

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29 July 2017

2

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29 July 2017

376-386

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29 July 2017

Target site occupancy: emerging generalizations from clinical and preclinical studies

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The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats

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NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy

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1 reference

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1 reference

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The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors

1 reference

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GABA-based therapeutic approaches: GABAA receptor subtype functions

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GABA-A receptors: a viable target for novel anxiolytics?

1 reference

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Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology

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28 July 2018

Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.

1 reference

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Positioning of the alpha-subunit isoforms confers a functional signature to gamma-aminobutyric acid type A receptors.

1 reference

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GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.

1 reference

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Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety

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28 July 2018

Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human [...]

1 reference

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Endogenous [3H]flunitrazepam binding in human embryonic kidney cell line 293.

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Diazepam impairs acquisition but not performance in the Morris water maze

1 reference

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The effect of subunit composition of rat brain GABAA receptors on channel function

1 reference

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Identification of receptor domains that modify ligand binding to 5-hydroxytryptamine2 and 5-hydroxytryptamine1c serotonin receptors

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A single histidine in GABAA receptors is essential for benzodiazepine agonist binding

1 reference

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Research in anxiety disorders: from the bench to the bedside

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World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision

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Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.

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Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex

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Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.

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Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice.

1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepine site inverse agonists and locomotor activity in rats: bimodal and biphasic influence

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074611

12 December 2020

based on heuristic

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Identifiers

10.1016/J.PNPBP.2010.01.004

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

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Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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