(Q33851314)

29 July 2017

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title

Determinants of passive drug entry into the central nervous system (English)

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29 July 2017

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Habgood MD

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29 July 2017

Begley DJ

series ordinal

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29 July 2017

Abbott NJ

series ordinal

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29 July 2017

publication date

1 April 2000

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Cellular and Molecular Neurobiology

29 July 2017

published in

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

231-253

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Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study

29 July 2017

cites work

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12 December 2020

Hydrogen bonding. 32. An analysis of water-octanol and water-alkane partitioning and the delta log P parameter of seiler.

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12 December 2020

Tight-junctional modification as the basis of osmotic opening of the blood-brain barrier

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12 December 2020

Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain.

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12 December 2020

Implantable microencapsulated dopamine (DA): a new approach for slow-release DA delivery into brain tissue

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12 December 2020

Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells

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12 December 2020

Iron-chelation therapy with oral deferiprone in patients with thalassemia major

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12 December 2020

Immunocytochemical localization of endopeptidase 24.15 in rat brain

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12 December 2020

Systemic toxic effects associated with high-dose verapamil infusion and chemotherapy administration

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12 December 2020

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

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12 December 2020

Protein size and cerebrospinal fluid composition

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12 December 2020

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

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12 December 2020

Brain Uptake of Phenytoin, Phenobarbital, and Diazepam

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12 December 2020

Brain uptake of benzodiazepines: effects of lipophilicity and plasma protein binding

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12 December 2020

Lack of correlation between tight junction morphology and permeability properties in developing choroid plexus

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12 December 2020

Brain drug delivery of small molecules using immunoliposomes

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12 December 2020

Prodrugs. Do they have advantages in clinical practice?

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12 December 2020

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

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12 December 2020

Determination of antibiotic lipophilicity with a micromethod: application to brain permeability in man and rats

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12 December 2020

Liposome targeting to mouse brain: mannose as a recognition marker

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12 December 2020

Morphology of blood-brain interfaces

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12 December 2020

Inflammatory mediators and modulation of blood-brain barrier permeability

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12 December 2020

Comparison of lipid-mediated blood-brain-barrier penetrability in neonates and adults

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12 December 2020

Electrical resistance of muscle capillary endothelium.

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12 December 2020

Lipid solubility and drug penetration of the blood brain barrier

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12 December 2020

Modulation of doxorubicin concentration by cyclosporin A in brain and testicular barrier tissues expressing P-glycoprotein in rats

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12 December 2020

Use of implantable pumps for central nervous system drug infusions to treat neurological disease

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12 December 2020

Probenecid inhibition of the outward transport of fluorescein across the human blood-retina barrier.

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12 December 2020

Electrical resistance of brain microvascular endothelium

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12 December 2020

Acidic antiinflammatory agents--correlations of some physical, pharmacological and clinical data

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12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

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12 December 2020

A prodrug of ADTN: Selectivity of dopaminergic action and brain levels of ADTN

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12 December 2020

Anesthetic potencies of n-alkanols: results of additivity and solubility studies suggest a mechanism of action similar to that for conventional inhaled anesthetics

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12 December 2020

Opening of the blood‐brain barrier by acute elevation of intracarotid pressure

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12 December 2020

Role of P-glycoprotein in the blood-brain transport of colchicine and vinblastine

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12 December 2020

Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design

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12 December 2020

Phenethylamine content of human urine and rat brain, its alterations in pathological conditions and after drug administration

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12 December 2020

Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability

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12 December 2020

Pharmacokinetics of interstitial delivery of carmustine, 4-hydroperoxycyclophosphamide, and paclitaxel from a biodegradable polymer implant in the monkey brain

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12 December 2020

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

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12 December 2020

The nature of the decrease in blood-cerebrospinal fluid barrier exchange during postnatal brain development in the rat.

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12 December 2020

Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injection

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12 December 2020

Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor.

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12 December 2020

Neurotoxicity of X-ray contrast media. Relation to lipid solubility and blood-brain barrier permeability

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12 December 2020

Pharmacological modification of bradykinin induced breakdown of the blood-brain barrier.

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12 December 2020

Is the multidrug transporter a flippase?

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12 December 2020

Penetration of 14C-inulin and 14C-sucrose into brain, cerebrospinal fluid, and skeletal muscle of developing rats

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12 December 2020

Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications

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12 December 2020

Comparative brain and plasma pharmacokinetics and anticancer activities of chlorambucil and melphalan in the rat.

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12 December 2020

Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7.

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12 December 2020

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

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12 December 2020

Distribution and Elimination of Poly(methyl-2-14C-methacrylate) Nanoparticle Radioactivity after Injection in Rats and Mice

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12 December 2020

Electrical resistance of a capillary endothelium

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats

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12 December 2020

Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potential

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12 December 2020

Modulation of tight junction structure in blood-brain barrier endothelial cells. Effects of tissue culture, second messengers and cocultured astrocytes

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12 December 2020

Overcoming multidrug resistance in Chinese hamster ovary cells in vitro by cyclosporin A (Sandimmune) and non-immunosuppressive derivatives

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12 December 2020

Junctions in the meninges and marginal glia

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12 December 2020

The Fine Structure of the Choroid Plexus: Adult and Developmental Stages

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12 December 2020

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.

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12 December 2020

Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.

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12 December 2020

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

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12 December 2020

Availability of liposome content to the nervous system. Liposomes and the blood-brain barrier

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12 December 2020

P-glycoprotein content and mediation of vincristine efflux: correlation with the level of differentiation in luminal epithelium of mouse small intestine.

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12 December 2020

Pharmacokinetics of chlorambucil-tertiary butyl ester, a lipophilic chlorambucil derivative that achieves and maintains high concentrations in brain

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12 December 2020

Determinants of benzodiazepine brain uptake: lipophilicity versus binding affinity

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12 December 2020

Direct stereotactic intracerebral injection of monoclonal antibodies and their fragments: a potential approach to brain tumor immunotherapy

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12 December 2020

Functional involvement of P-glycoprotein in blood-brain barrier

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12 December 2020

Controlled release of dopamine from a polymeric brain implant: in vivo characterization

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12 December 2020

Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery

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12 December 2020

Molecular Factors Influencing Drug Transfer across the Blood-Brain Barrier

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12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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12 December 2020

The biochemistry of P-glycoprotein-mediated multidrug resistance

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12 December 2020

Permeability of the blood brain barrier by the bradykinin agonist, RMP-7: evidence for a sensitive, auto-regulated, receptor-mediated system

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12 December 2020

Increased efflux of vincristine, but not of daunorubicin, associated with the murine multidrug resistance protein (MRP).

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12 December 2020

Transcytosis of protein through the mammalian cerebral epithelium and endothelium. III. Receptor-mediated transcytosis through the blood-brain barrier of blood-borne transferrin and antibody against the transferrin receptor.

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12 December 2020

Efficacy of oral dalargin-loaded nanoparticle delivery across the blood-brain barrier

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12 December 2020

Affinity of antineoplastic amino acid drugs for the large neutral amino acid transporter of the blood-brain barrier

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12 December 2020

Fracture faces of cell junctions in cerebral endothelium during normal and hyperosmotic conditions

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12 December 2020

Melphalan concentration dependent plasma protein binding in healthy humans and rats

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12 December 2020

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells

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12 December 2020

Junctions between intimately apposed cell membranes in the vertebrate brain

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12 December 2020

Systemic cytokine administration can affect blood-brain barrier permeability in the rat

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12 December 2020

Drug delivery to brain and the role of carrier-mediated transport.

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12 December 2020

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

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12 December 2020

The pH dependent "lipid solubility" of drugs

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12 December 2020

Effectiveness of the nitrosoureas as a function of their lipid solubility in the chemotherapy of experimental rat brain tumors

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12 December 2020

Selective permeability of the blood-uterine lumen barrier in rats: importance of lipid solubility

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12 December 2020

Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain

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12 December 2020

Double replica technique applied to choroid plexus from early foetal sheep: completeness and complexity of tight junctions

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12 December 2020

Intravenous RMP-7 selectively increases uptake of carboplatin into rat brain tumors.

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12 December 2020

Identifiers

DOI

10.1023/A:1007001923498

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Dimensions Publication ID

29 July 2017

1053312255

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