(Q33716182)

28 July 2017

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title

p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials (English)

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28 July 2017

J C Lee

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28 July 2017

S Kassis

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28 July 2017

S Kumar

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28 July 2017

A Badger

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28 July 2017

J L Adams

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28 July 2017

publication date

1 May 1999

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Pharmacology & Therapeutics

28 July 2017

published in

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28 July 2017

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28 July 2017

issue

2-3

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28 July 2017

page(s)

389-397

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Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.

28 July 2017

cites work

1 reference

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7 January 2021

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

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7 January 2021

1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency

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7 January 2021

Kinetic mechanisms of the forward and reverse pp60c-src tyrosine kinase reactions.

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7 January 2021

How MAP kinases are regulated

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7 January 2021

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit

1 reference

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7 January 2021

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Pyrroles and other heterocycles as inhibitors of p38 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1 reference

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7 January 2021

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

1 reference

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7 January 2021

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2, 3-b]pyridine (RWJ 68354): a potent and selective p38 kinase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

The stress-activated protein kinase subfamily of c-Jun kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&F 86002

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Effect of SK&F 86002 on cytokine production by human monocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

The primary structure of p38 gamma: a new member of p38 group of MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Kinetic Mechanism for p38 MAP Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

PRAK, a novel protein kinase regulated by the p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Identification of stathmin as a novel substrate for p38 delta

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFα- and hydrogen peroxide-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

p38-2, a novel mitogen-activated protein kinase with distinct properties.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

The structure of mitogen-activated protein kinase p38 at 2.1-A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Structural basis of inhibitor selectivity in MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Identification of a signal for rapid export of proteins from the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Crystal structure of p38 mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900008-X

7 January 2021

10.1016/S0163-7258(99)00008-X

Identifiers

DOI

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28 July 2017

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