(Q33683779)

28 July 2017

1 reference

title

Oxygen, oxidative stress, hypoxia, and heart failure (English)

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28 July 2017

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Frank J Giordano

1 reference

28 July 2017

language of work or name

English

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publication date

1 March 2005

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Journal of Clinical Investigation

28 July 2017

published in

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28 July 2017

volume

115

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28 July 2017

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28 July 2017

page(s)

500-508

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NO and superoxide: opposite ends of the seesaw in cardiac contractility

28 July 2017

cites work

1 reference

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21 June 2018

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Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling

21 June 2018

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Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

21 June 2018

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21 June 2018

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The potential role of ventricular compressive therapy

21 June 2018

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A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression

21 June 2018

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21 June 2018

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21 June 2018

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Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death

21 June 2018

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Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling

21 June 2018

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21 June 2018

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Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling

21 June 2018

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Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

21 June 2018

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Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes

21 June 2018

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21 June 2018

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Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment

21 June 2018

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Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

21 June 2018

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ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes

21 June 2018

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Mitochondrial Production of Oxygen Radical Species and the Role of Coenzyme Q as an Antioxidant

21 June 2018

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H2O2-induced higher order chromatin degradation: a novel mechanism of oxidative genotoxicity

21 June 2018

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A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.

21 June 2018

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Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging

21 June 2018

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Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases

21 June 2018

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Molecular basis of the VHL hereditary cancer syndrome

21 June 2018

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Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production.

21 June 2018

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Simvastatin prevents angiotensin II-induced cardiac alteration and oxidative stress

21 June 2018

1 reference

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Paradigms and pitfalls of yeast longevity research

21 June 2018

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Role of oxidative stress in myocardial hypertrophy and failure

21 June 2018

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Reactive oxygen species and regulation of gene expression

21 June 2018

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21 June 2018

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The oxidative stress hypothesis of congestive heart failure: radical thoughts

21 June 2018

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Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

21 June 2018

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Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

21 June 2018

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HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

21 June 2018

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Mouse models for mitochondrial disease

21 June 2018

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Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes.

21 June 2018

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Cardiac energy metabolism: models of cellular respiration

21 June 2018

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Effect of carvedilol on survival in severe chronic heart failure

21 June 2018

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A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function

21 June 2018

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Cardiac toxicity of singlet oxygen: implication in reperfusion injury

21 June 2018

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A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease

21 June 2018

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Redox control of protein degradation

21 June 2018

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Angiogenesis: the role of the microenvironment in flipping the switch.

21 June 2018

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G alpha(i) and G alpha(o) are target proteins of reactive oxygen species

21 June 2018

1 reference

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Reactive oxygen species in cell signaling

21 June 2018

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Reactive oxygen species, cell signaling, and cell injury

21 June 2018

1 reference

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Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis

21 June 2018

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Reactive oxygen species and oxidative DNA damage.

21 June 2018

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NAD(P)H oxidase: role in cardiovascular biology and disease

21 June 2018

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Early expression of angiogenesis factors in acute myocardial ischemia and infarction

21 June 2018

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Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury

21 June 2018

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The nature of antioxidant defense mechanisms: a lesson from transgenic studies

21 June 2018

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

21 June 2018

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Causative role of oxyradicals in myocardial stunning: a proven hypothesis. A brief review of the evidence demonstrating a major role of reactive oxygen species in several forms of postischemic dysfunction

21 June 2018

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Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes

21 June 2018

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Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction

21 June 2018

1 reference

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 June 2018

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

21 June 2018

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Cancer-Preventive Selenocompounds Induce a Specific Redox Modification of Cysteine-Rich Regions in Ca2+- Dependent Isoenzymes of Protein Kinase C

21 June 2018

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Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability

21 June 2018

1 reference

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Free radicals enhance Na+/Ca2+ exchange in ventricular myocytes

21 June 2018

1 reference

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The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricular myocytes

21 June 2018

1 reference

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The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice

21 June 2018

1 reference

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Oxidative stress: the paradox of aerobic life

21 June 2018

1 reference

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Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Catalase: a tetrameric enzyme with four tightly bound molecules of NADPH.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Role of oxidized low density lipoprotein in atherogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Mechanism of the membrane depolarization induced by oxidative stress in guinea-pig ventricular cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Nitroso-redox balance in the cardiovascular system

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Rationale, design and organisation of an efficacy and safety study of oxypurinol added to standard therapy in patients with NYHA class III - IV congestive heart failure

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?

30 October 2018

1 reference

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Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Involvement of reactive oxygen species in cardiotrophin-1-induced proliferation of cardiomyocytes differentiated from murine embryonic stem cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Regulation of calcineurin by oxidative stress

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Redox modulation of the inotropic response to dobutamine is impaired in patients with heart failure

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Free radical-induced protein modification and inhibition of Ca2+-ATPase of cardiac sarcoplasmic reticulum.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Increased myocardial NADPH oxidase activity in human heart failure

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Activation of NADPH oxidase during progression of cardiac hypertrophy to failure

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in in vivo murine pressure-overload model

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Vitamin C inhibits endothelial cell apoptosis in congestive heart failure

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Possible mechanism(s) of arachidonic acid-induced intracellular acidosis in rat cardiac myocytes.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Inducible nitric-oxide synthase generates superoxide from the reductase domain

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Interaction of reactive oxygen species with ion transport mechanisms.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1052012

Chronic ethanol exposure increases lipopigment accumulation in human heart

30 October 2018

1 reference

12 December 2020

Vitamin E supplementation and cardiovascular events in high-risk patients

1 reference

12 December 2020

[5] Diversity of glutathione peroxidases

1 reference

12 December 2020

Nature of the cardiomyocyte injury induced by lipid hydroperoxides

1 reference

12 December 2020

Extracellular superoxide dismutase transgene overexpression preserves postischemic myocardial function in isolated murine hearts

1 reference

12 December 2020

Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

1 reference

12 December 2020

Partial Left Ventriculectomy to Treat End-Stage Heart Disease

1 reference

12 December 2020

Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process

1 reference

12 December 2020

Lipid peroxidation and antioxidant enzymes in isoproterenol induced oxidative stress in rat tissues

1 reference

12 December 2020

Activation of matrix metalloproteinases in the failing human heart: breaking the tie that binds

1 reference

12 December 2020

Mechanisms of protection of catalase by NADPH. Kinetics and stoichiometry

1 reference

12 December 2020

Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis

1 reference

12 December 2020

Myocyte loss in chronic heart failure

1 reference

12 December 2020

Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium

1 reference

12 December 2020

"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium

1 reference

12 December 2020

Novel myofilament Ca2+-sensitizing property of xanthine oxidase inhibitors

1 reference

12 December 2020

Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II

1 reference

12 December 2020

Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure

1 reference

12 December 2020

cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI24408

1 reference

28 July 2017

1 reference

28 July 2017

1 reference