(Q33598627)

28 July 2017

title

Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist (English)

1 reference

28 July 2017

Mònica Aparici

0 references

Paul Eastwood

1 reference

28 July 2017

Cristina Esteve

1 reference

28 July 2017

Jacob González

1 reference

28 July 2017

Silvia Fonquerna

1 reference

28 July 2017

Josep Aiguadé

1 reference

28 July 2017

Inés Carranco

1 reference

28 July 2017

Teresa Doménech

1 reference

28 July 2017

Montserrat Miralpeix

1 reference

28 July 2017

Joan Albertí

1 reference

28 July 2017

Mónica Córdoba

1 reference

28 July 2017

Raquel Fernández

1 reference

28 July 2017

Mercè Pont

1 reference

28 July 2017

Núria Godessart

1 reference

28 July 2017

Neus Prats

1 reference

28 July 2017

María Isabel Loza

1 reference

28 July 2017

María Isabel Cadavid

1 reference

28 July 2017

Arsenio Nueda

1 reference

28 July 2017

Bernat Vidal

1 reference

28 July 2017

publication date

20 December 2010

1 reference

ACS Medicinal Chemistry Letters

28 July 2017

published in

1 reference

28 July 2017

1 reference

28 July 2017

1 reference

28 July 2017

page(s)

213-218

1 reference

Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

A(2B) adenosine receptors in immunity and inflammation.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Purinergic receptors in airway epithelia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Host A(2B) adenosine receptors promote carcinoma growth

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

A2B adenosine receptor gene deletion attenuates murine colitis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Enhanced mast cell activation in mice deficient in the A2b adenosine receptor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

The A2B adenosine receptor protects against inflammation and excessive vascular adhesion

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

A comprehensive listing of bioactivation pathways of organic functional groups

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Discovery of potent and selective bicyclic A(2B) adenosine receptor antagonists via bioisosteric amide replacement

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Release of ATP during host cell killing by enteropathogenic E. coli and its role as a secretory mediator

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018059

Resolution of bronchial hyperresponsiveness and pulmonary inflammation is associated with IL-3 and tissue leukocyte apoptosis

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900298

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Adenosine regulates the production of interleukin-6 by human gingival fibroblasts via cyclic AMP/protein kinase A pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900298

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML100249E

1 reference

28 July 2017

1 reference

28 July 2017

1 reference