(Q33540082)

27 July 2017

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title

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation (English)

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27 July 2017

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Dennis PB

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27 July 2017

Fumagalli S

series ordinal

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27 July 2017

Thomas G

series ordinal

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27 July 2017

publication date

1 February 1999

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Current Opinion in Genetics & Development

27 July 2017

published in

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27 July 2017

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27 July 2017

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27 July 2017

page(s)

49-54

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

27 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

TOR controls translation initiation and early G1 progression in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

TOR2 is required for organization of the actin cytoskeleton in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Immunophilins in the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

HEAT repeats in the Huntington's disease protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

TOR signalling and control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

The mRNA 5' cap-binding protein eIF4E and control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Regulation of eIF-4E BP1 phosphorylation by mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

The modular phosphorylation and activation of p70s6k.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Modulation of transcription of rRNA genes by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

RB kinases and RB-binding proteins: new points of view

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Atypical protein kinase Clambda binds and regulates p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Alpha 4 associates with protein phosphatases 2A, 4, and 6

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Autophagy and related mechanisms of lysosome-mediated protein degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

A protein conjugation system essential for autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

Amino acid availability regulates p70 S6 kinase and multiple translation factors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

A novel inhibitor of cap-dependent translation initiation in yeast: p20 competes with eIF4G for binding to eIF4E.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2980007-0

7 January 2021

10.1016/S0959-437X(99)80007-0

Identifiers

DOI

1 reference

27 July 2017

1 reference