(Q33427852)

26 July 2017

title

The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease (English)

1 reference

ubiquitin-proteasome system

26 July 2017

0 references

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1 reference

26 July 2017

Leonard Petrucelli

1 reference

26 July 2017

John S Bett

1 reference

26 July 2017

Casey Cook

series ordinal

1 reference

26 July 2017

language of work or name

English

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publication date

8 April 2009

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26 July 2017

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26 July 2017

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26 July 2017

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26 July 2017

page(s)

e5128

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Creative Commons Attribution 4.0 International

26 July 2017

start time

8 April 2009

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease

1 reference

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Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases

21 June 2018

1 reference

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Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation

21 June 2018

1 reference

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Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662425

Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).

21 June 2018

1 reference

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Disease-associated prion protein oligomers inhibit the 26S proteasome

21 June 2018

1 reference

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Histone deacetylase inhibitors as therapeutics for polyglutamine disorders

21 June 2018

1 reference

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Proteasome inhibition and Parkinson's disease modeling

21 June 2018

1 reference

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Expanded polyglutamines impair synaptic transmission and ubiquitin-proteasome system in Caenorhabditis elegans

21 June 2018

1 reference

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Aggregation and proteasome: the case of elongated polyglutamine aggregation in spinal and bulbar muscular atrophy.

21 June 2018

1 reference

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Progressive disruption of cellular protein folding in models of polyglutamine diseases.

21 June 2018

1 reference

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Application and analysis of the GFPu family of ubiquitin-proteasome system reporters

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662425

Proteasome function is inhibited by polyglutamine-expanded ataxin-1, the SCA1 gene product

21 June 2018

1 reference

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Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 June 2018

1 reference

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Inefficient degradation of truncated polyglutamine proteins by the proteasome

21 June 2018

1 reference

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Modulating huntingtin half-life alters polyglutamine-dependent aggregate formation and cell toxicity

21 June 2018

1 reference

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Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662425

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

21 June 2018

1 reference

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Are Huntington's and polyglutamine-based ataxias proteasome storage diseases?

21 June 2018

1 reference

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 June 2018

1 reference

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Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients

21 June 2018

1 reference

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Impairment of the ubiquitin-proteasome system by protein aggregation

21 June 2018

1 reference

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 June 2018

1 reference

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 June 2018

1 reference

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662425

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662425

Global changes to the ubiquitin system in Huntington's disease.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

Generalized brain and skin proteasome inhibition in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

Monitoring of ubiquitin-dependent proteolysis with green fluorescent protein substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

A transgenic mouse model of the ubiquitin/proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

Proteasome degrades soluble expanded polyglutamine completely and efficiently

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005128

Neuronal induction of the immunoproteasome in Huntington's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662425

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19352500

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0005128

1 reference

26 July 2017

0 references

1 reference

26 July 2017

1 reference