(Q33458331)

27 July 2017

title

IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin (English)

1 reference

27 July 2017

0 references

Ali Khoshnan

1 reference

27 July 2017

Jan Ko

1 reference

27 July 2017

Simona Tescu

1 reference

27 July 2017

Patrick Brundin

1 reference

27 July 2017

Paul H Patterson

1 reference

27 July 2017

language of work or name

English

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publication date

2 June 2009

1 reference

27 July 2017

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27 July 2017

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27 July 2017

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27 July 2017

page(s)

e5768

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Creative Commons Attribution 4.0 International

27 July 2017

start time

2 June 2009

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

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21 June 2018

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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

21 June 2018

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21 June 2018

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21 June 2018

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Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

21 June 2018

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Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB

21 June 2018

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Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.

21 June 2018

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Huntingtin inhibits caspase-3 activation

21 June 2018

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Regulation and function of IKK and IKK-related kinases

21 June 2018

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BCL-xL regulates synaptic plasticity

21 June 2018

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IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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IKK mediates ischemia-induced neuronal death

21 June 2018

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p53 tumor suppressor protein regulates the levels of huntingtin gene expression

21 June 2018

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Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1).

21 June 2018

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Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

21 June 2018

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

21 June 2018

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Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

21 June 2018

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Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 June 2018

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21 June 2018

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21 June 2018

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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 June 2018

1 reference

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 June 2018

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Calcium regulation of neuronal gene expression

21 June 2018

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Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

21 June 2018

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21 June 2018

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The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

21 June 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 June 2018

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 June 2018

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N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease

21 January 2018

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Wild-type huntingtin protects neurons from excitotoxicity

21 January 2018

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Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain.

21 January 2018

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Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

21 January 2018

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p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

21 January 2018

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Cell cycle activation linked to neuronal cell death initiated by DNA damage

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005768

Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005768

Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005768

Microglial activation in presymptomatic Huntington's disease gene carriers

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005768

Hypothalamic involvement in Huntington's disease: an in vivo PET study

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005768

Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005768

Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19488402

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phosphorylation of Bcl-xL after spinal cord injury

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19488402

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0005768

1 reference

27 July 2017

0 references

1 reference

27 July 2017

1 reference