(Q31148881)

29 June 2017

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title

Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors (English)

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29 June 2017

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Anders Björklund

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Deniz Kirik

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29 June 2017

publication date

1 July 2003

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29 June 2017

published in

Trends in Neurosciences

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29 June 2017

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29 June 2017

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29 June 2017

page(s)

386-392

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Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

29 June 2017

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Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model

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Intraneuronal aggregate formation and cell death after viral expression of expanded polyglutamine tracts in the adult rat brain.

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Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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A polymorphic DNA marker genetically linked to Huntington's disease

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Huntington's disease in Venezuela: 7 years of follow-up on symptomatic and asymptomatic individuals

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A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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7 January 2021

Neuropathology in mice expressing human alpha-synuclein

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

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7 January 2021

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

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7 January 2021

Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

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7 January 2021

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.

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Identifiers

DOI

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29 June 2017

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