(Q30981408)

28 June 2017

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title

Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data (English)

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28 June 2017

Mark D Black

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28 June 2017

publication date

26 January 2005

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28 June 2017

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28 June 2017

volume

179

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28 June 2017

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28 June 2017

page(s)

154-163

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Cloning by functional expression of a member of the glutamate receptor family

28 June 2017

cites work

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12 December 2020

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

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12 December 2020

Intra- and interstrain differences in models of "behavioral despair".

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12 December 2020

Receptor changes and LTP: an analysis using aniracetam, a drug that reversibly modifies glutamate (AMPA) receptors

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12 December 2020

Splice variants of glutamate receptor subunits 2 and 3 in striatal projection neurons

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12 December 2020

Sustained ethanol inhibition of native AMPA receptors on medial septum/diagonal band (MS/DB) neurons

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12 December 2020

Working memory dysfunction in schizophrenia

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12 December 2020

A family of AMPA-selective glutamate receptors

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12 December 2020

An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study

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12 December 2020

NMDA receptor subunits: diversity, development and disease

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12 December 2020

Glutamate receptor channels: novel properties and new clones

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12 December 2020

The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys.

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12 December 2020

Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus

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12 December 2020

A new benzodiazepine pharmacology.

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12 December 2020

NMDA and AMPA/kainate receptors are involved in the anticonvulsant activity of riluzole in DBA/2 mice

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12 December 2020

Serotonergic mechanisms involved in the attentional and vigilance task performance of rats and the palliative action of aniracetam

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12 December 2020

A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in a learning-dependent task

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12 December 2020

NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders

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12 December 2020

Facilitation of glutamate receptors enhances memory

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12 December 2020

Modulation of AMPA/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus.

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12 December 2020

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam

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12 December 2020

The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment

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12 December 2020

Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model

1 reference

12 December 2020

Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: a case series

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12 December 2020

Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain

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12 December 2020

Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion

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12 December 2020

Glutamatergic and dopaminergic afferents to the prefrontal cortex regulate spatial working memory in rats

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12 December 2020

AMPA receptor modulators as cognitive enhancers

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12 December 2020

Control of kinetic properties of AMPA receptor channels by nuclear RNA editing

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12 December 2020

Therapeutic N-methyl-D-aspartate receptor antagonists: will reality meet expectation?

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12 December 2020

Regional preferences of AMPA receptor modulators determined through agonist binding autoradiography

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12 December 2020

Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors.

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12 December 2020

Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors.

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12 December 2020

A centrally active drug that modulates AMPA receptor gated currents

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12 December 2020

Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors

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12 December 2020

Enhancement by an ampakine of memory encoding in humans.

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12 December 2020

Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex

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12 December 2020

Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents

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12 December 2020

Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

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12 December 2020

GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: a reverse transcriptase-polymerase chain reaction (RT-PCR) study

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12 December 2020

Expression of AMPA receptor flip and flop mRNAs in the nucleus accumbens and prefrontal cortex after neonatal ventral hippocampal lesions

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12 December 2020

Effect of AMPA receptor modulators on hippocampal and cortical function.

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12 December 2020

Apomorphine-induced hypoattention in rats and reversal of the choice performance impairment by aniracetam

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12 December 2020

A molecular determinant for submillisecond desensitization in glutamate receptors

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12 December 2020

Aniracetam enhances glutamatergic transmission in the prefrontal cortex of stroke-prone spontaneously hypertensive rats

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12 December 2020

Effects of cyclothiazide on synaptic responses in slices of adult and neonatal rat hippocampus.

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12 December 2020

Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

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12 December 2020

Multideterminant role of calcium in hippocampal synaptic plasticity

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12 December 2020

AMPA Receptor Facilitation Accelerates Fear Learning without Altering the Level of Conditioned Fear Acquired

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12 December 2020

Critical role of brain-derived neurotrophic factor in mood disorders

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12 December 2020

Chronic elevation of brain-derived neurotrophic factor by ampakines

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12 December 2020

Effects of intrahippocampal aniracetam treatment on Y-maze avoidance learning performance and behavioral long-term potentiation in dentate gyrus in rat.

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12 December 2020

Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo

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12 December 2020

The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies

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12 December 2020

Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism

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12 December 2020

Facilitative effects of the ampakine CX516 on short-term memory in rats: correlations with hippocampal neuronal activity.

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12 December 2020

Effect of scopolamine and nootropic drugs on rewarded alternation in a T-maze.

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12 December 2020

Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro

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12 December 2020

Expression of messenger RNAs encoding ionotropic glutamate receptors in rat brain: regulation by haloperidol

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12 December 2020

Selective alterations in ionotropic glutamate receptors in the anterior cingulate cortex in schizophrenia

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12 December 2020

Interactive effects of subanesthetic ketamine and haloperidol in healthy humans

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12 December 2020

Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain

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12 December 2020

Structure-Based Rational Design of Chemical Ligands for AMPA-Subtype Glutamate Receptors

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12 December 2020

Prefrontal function in schizophrenia: confounds and controversies

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12 December 2020

Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing

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12 December 2020

Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 mice

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12 December 2020

The role of postsynaptic calcium in the induction of long-term potentiation

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12 December 2020

Neurotrophic factors in Alzheimer's and Parkinson's disease brain

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12 December 2020

Effects of an AMPA receptor modulator on methamphetamine-induced hyperactivity in rats

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12 December 2020

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys

1 reference

12 December 2020

Aniracetam. An overview of its pharmacodynamic and pharmacokinetic properties, and a review of its therapeutic potential in senile cognitive disorders

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12 December 2020

Glutamate neurotoxicity and diseases of the nervous system

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12 December 2020

New developments in the molecular pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and kainate receptors

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12 December 2020

Potential nootropic agents, 4-alkoxy-2-(1-piperazinyl)quinazoline derivatives

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12 December 2020

Facilitative effects of the ampakine CX516 on short-term memory in rats: enhancement of delayed-nonmatch-to-sample performance.

1 reference

12 December 2020

Glutamate receptor expression in schizophrenic brain

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12 December 2020

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

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12 December 2020

The role of excitotoxicity in neurodegenerative disease: implications for therapy

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12 December 2020

AMPA receptor trafficking and long-term potentiation

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12 December 2020

Recent advances in the study of AMPA receptors

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12 December 2020

Regional specific increases of [3H]AMPA binding and mRNA expression of AMPA receptors in the brain of mu-opioid receptor knockout mice

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12 December 2020

Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.

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12 December 2020

Mammalian ionotropic glutamate receptors.

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12 December 2020

WEB 1881 FU ameliorates impairment of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task.

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12 December 2020

Effects of aniracetam on delayed matching-to-sample performance of monkeys and pigeons.

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12 December 2020

Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes

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12 December 2020

Recent advances in the phencyclidine model of schizophrenia

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12 December 2020

A profile of the behavioral changes produced by facilitation of AMPA-type glutamate receptors

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12 December 2020

Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants

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12 December 2020

Synaptic plasticity and AMPA receptor trafficking

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12 December 2020

Study of a new schizophrenomimetic drug; sernyl.

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12 December 2020

Identification of a site in glutamate receptor subunits that controls calcium permeability

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12 December 2020

7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization.

1 reference

12 December 2020

The Biochemistry of Memory: A New and Specific Hypothesis

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12 December 2020

NMDA receptor hypofunction model of schizophrenia

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12 December 2020

Synergistic interactions between ampakines and antipsychotic drugs

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12 December 2020

Enhanced glutamatergic neurotransmission facilitates classical conditioning in the freely moving rat.

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12 December 2020

Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit

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12 December 2020

Aniracetam: its novel therapeutic potential in cerebral dysfunctional disorders based on recent pharmacological discoveries.

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12 December 2020

Synaptic excitation mediated by AMPA receptors in rat cerebellar slices is selectively enhanced by aniracetam and cyclothiazide

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12 December 2020

LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease.

1 reference

12 December 2020

Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans.

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12 December 2020

Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer

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12 December 2020

GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?

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12 December 2020

LY404187: a novel positive allosteric modulator of AMPA receptors

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12 December 2020

Effects of single or repeated restraint stress on GluR1 and GluR2 flip and flop mRNA expression in the hippocampal formation.

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12 December 2020

Antidepressant-like effects of aniracetam in aged rats and its mode of action

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12 December 2020

Effects of D-cycloserine and aniracetam on spatial learning in rats with entorhinal cortex lesions

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12 December 2020

Flip and flop variants of AMPA receptor subunits in the human cerebellum: implication for the selective vulnerability of Purkinje cells

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12 December 2020

Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiator.

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12 December 2020

Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease.

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12 December 2020

Role of AMPA receptor endocytosis in synaptic plasticity

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12 December 2020

Correlation between kinetics and RNA splicing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in neocortical neurons.

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12 December 2020

Aniracetam improves radial maze performance in rats

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12 December 2020

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate

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12 December 2020

Expression of transcripts encoding AMPA receptor subunits and associated postsynaptic proteins in the macaque brain

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12 December 2020

Impulsivity and AMPA receptors: aniracetam ameliorates impulsive behavior induced by a blockade of AMPA receptors in rats

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12 December 2020

A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia

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12 December 2020

Selective expression of heteromeric AMPA receptors driven by flip-flop differences

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12 December 2020

Psychological effects of a drug that facilitates brain AMPA receptors.

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12 December 2020

Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro

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12 December 2020

NMDA receptor pharmacology: perspectives from molecular biology

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12 December 2020

Stable expression of recombinant AMPA receptor subunits: binding affinities and effects of allosteric modulators

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12 December 2020

Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices

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12 December 2020

Aniracetam augments, and midazolam inhibits, the long-term potentiation in guinea-pig hippocampal slices

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12 December 2020

Molecular cloning and functional expression of glutamate receptor subunit genes

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12 December 2020

Syndromes of schizophrenia on factor analysis

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12 December 2020

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

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12 December 2020

Modulating excitatory synaptic neurotransmission: potential treatment for neurological disease?

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12 December 2020

The role of the prefrontal cortex in higher cognitive functions

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12 December 2020

Synchronization processes in the mechanisms of short-term memory in monkeys: the involvement of cholinergic and glutaminergic cortical structures

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12 December 2020

NMDA-antagonism (memantine): an alternative pharmacological therapeutic principle in Alzheimer's and vascular dementia

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12 December 2020

Regulation of kinetic properties of GluR2 AMPA receptor channels by alternative splicing.

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12 December 2020

10.1007/S00213-004-2065-6

Identifiers

DOI

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Dimensions Publication ID

28 June 2017

1030738633

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