(Q30749785)

26 June 2017

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title

Beta-secretase (BACE) as a drug target for Alzheimer's disease (English)

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26 June 2017

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Robert Vassar

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26 June 2017

language of work or name

English

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publication date

1 December 2002

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Advanced Drug Delivery Reviews

26 June 2017

published in

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26 June 2017

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26 June 2017

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26 June 2017

page(s)

1589-1602

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

26 June 2017

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Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.

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Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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7 January 2021

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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7 January 2021

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

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7 January 2021

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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7 January 2021

Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes

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7 January 2021

Generation of amyloid β protein from its precursor is sequence specific

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7 January 2021

Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

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7 January 2021

The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein

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7 January 2021

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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7 January 2021

Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

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7 January 2021

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

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7 January 2021

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

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7 January 2021

A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein

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7 January 2021

Expression analysis of BACE2 in brain and peripheral tissues

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7 January 2021

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

1 reference

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7 January 2021

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

1 reference

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7 January 2021

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

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7 January 2021

The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease.

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7 January 2021

Association studies using novel polymorphisms in BACE1 and BACE2.

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7 January 2021

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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7 January 2021

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

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7 January 2021

BACE2 functions as an alternative alpha-secretase in cells

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7 January 2021

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

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7 January 2021

Maturation and pro-peptide cleavage of beta-secretase

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7 January 2021

Processing of beta-secretase by furin and other members of the proprotein convertase family

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7 January 2021

Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.

1 reference

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7 January 2021

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

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7 January 2021

Prodomain processing of Asp1 (BACE2) is autocatalytic.

1 reference

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7 January 2021

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

1 reference

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7 January 2021

Phosphorylation regulates intracellular trafficking of beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6

7 January 2021

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6

7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

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7 January 2021

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6

7 January 2021

Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6

7 January 2021

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6

7 January 2021

Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900157-6

7 January 2021

Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide

1 reference

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7 January 2021

10.1016/S0169-409X(02)00157-6

Identifiers

DOI

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26 June 2017

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