(Q30498538)

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Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties

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Europe PubMed Central

PMC publication ID

9 October 2017

Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties (English)

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

1 reference

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inferred from title

Patrick M. Sexton

7

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

author name string

Katie Leach

1

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Richard E Loiacono

2

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Christian C Felder

3

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

David L McKinzie

4

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Adrian Mogg

5

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

David B Shaw

6

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Arthur Christopoulos

8

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Europe PubMed Central

PMC publication ID

9 October 2017

language of work or name

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publication date

25 November 2009

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Europe PubMed Central

PMC publication ID

9 October 2017

Neuropsychopharmacology

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Europe PubMed Central

PMC publication ID

9 October 2017

35

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Europe PubMed Central

PMC publication ID

9 October 2017

4

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

855-869

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.

1 reference

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

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Akt/GSK3 signaling in the action of psychotropic drugs

1 reference

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Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

1 reference

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A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

1 reference

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Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia

1 reference

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Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

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An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

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Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

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Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

1 reference

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Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors

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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders

1 reference

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Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

1 reference

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Schizophrenia as a GSK-3 dysregulation disorder

1 reference

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20 June 2018

Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia.

1 reference

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20 June 2018

Cholinergic modulation of cortical function

1 reference

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The role of acetylcholine in learning and memory

1 reference

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20 June 2018

Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: evidence for three distinct modes of receptor activation

1 reference

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20 June 2018

Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox

1 reference

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20 June 2018

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

1 reference

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20 June 2018

Effects of urea pretreatment on the binding properties of adenosine A1 receptors

1 reference

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Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

1 reference

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20 June 2018

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

20 June 2018

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

20 June 2018

M1-M5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

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Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system

1 reference

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Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

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Qualitative and quantitative assessment of relative agonist efficacy

1 reference

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Characterization of the subtype selectivity of the allosteric modulator heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl) ammonium bromide (C7/3-phth) at cloned muscarinic acetylcholine receptors

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Differential expression of D1 and D2 dopamine and m4 muscarinic acetylcholine receptor proteins in identified striatonigral neurons

1 reference

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Differential muscarinic receptor binding of acetylcholinesterase inhibitors in rat brain, human brain and Chinese hamster ovary cells expressing human receptors.

1 reference

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Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

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A personal view of pharmacology

1 reference

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Role of acidic amino acids in the allosteric modulation by gallamine of antagonist binding at the m2 muscarinic acetylcholine receptor

1 reference

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Use of chimeric muscarinic receptors to investigate epitopes involved in allosteric interactions

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The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart

1 reference

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Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes

1 reference

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Assessing the distribution of parameters in models of ligand-receptor interaction: to log or not to log.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

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Decreased muscarinic receptor binding in subjects with schizophrenia: a study of the human hippocampal formation.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

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Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

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Decreased density of muscarinic receptors in the superior temporal gyrusin schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

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Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

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Impairments of ERK signal transduction in the brain in a rat model of depression induced by neonatal exposure of clomipramine

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

21 January 2018

Allosteric modulation of muscarinic acetylcholine receptors.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

21 January 2018

Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

21 January 2018

Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

21 January 2018

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

21 January 2018

Allosteric Modulation of G Protein–Coupled Receptors

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

21 January 2018

Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

21 January 2018

New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug).

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

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Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

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Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-o

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

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Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist

1 reference

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Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

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M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

26 November 2018

Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

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Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

26 November 2018

Changes of cooperativity between N-methylscopolamine and allosteric modulators alcuronium and gallamine induced by mutations of external loops of muscarinic M(3) receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

26 November 2018

Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

26 November 2018

Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

26 November 2018

The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

26 November 2018

The density of muscarinic M1 receptors is decreased in the caudate-putamen of subjects with schizophrenia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055367

26 November 2018

Bisquaternary Ligands of the Common Allosteric Site of M2Acetylcholine Receptors: Search for the Minimum Essential Distances between the Pharmacophoric Elements

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2009.194

21 January 2018

Site-directed mutagenesis reveals two epitopes involved in the subtype selectivity of the allosteric interactions of gallamine at muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of AKT1 with schizophrenia confirmed in a Japanese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/NPP.2009.194

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

ResearchGate publication ID

0 references

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