(Q30497635)

English

Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in Vivo

scientific article published on October 7, 2010

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scholarly article

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Europe PubMed Central

PMC publication ID

27 September 2017

Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo (English)

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in Vivo (English)

1 reference

10.1074/JBC.M110.166892

https://api.crossref.org/works/10.1074/JBC.M110.166892

29 July 2024

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based on heuristic

inferred from title

monoclonal antibody

1 reference

based on heuristic

inferred from title

antibody specificity

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

23

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Zhiqiang An

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

author name string

Helmut Glantschnig

1

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Ping Lu

3

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Europe PubMed Central

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27 September 2017

Salvatore Vitelli

5

1 reference

Europe PubMed Central

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27 September 2017

Lingyi Huang

6

1 reference

Europe PubMed Central

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27 September 2017

Peter Haytko

7

1 reference

Europe PubMed Central

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27 September 2017

Tara Cusick

8

1 reference

Europe PubMed Central

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27 September 2017

Cheryl Ireland

9

1 reference

Europe PubMed Central

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27 September 2017

Robin Ernst

11

1 reference

Europe PubMed Central

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27 September 2017

Nan Wei

12

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Pascale Nantermet

13

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Fabio Talamo

16

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Laura Orsatti

17

1 reference

Europe PubMed Central

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27 September 2017

Punam Sandhu

19

1 reference

Europe PubMed Central

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27 September 2017

Donald Kimmel

20

1 reference

Europe PubMed Central

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27 September 2017

Osvaldo Flores

21

1 reference

Europe PubMed Central

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27 September 2017

William Strohl

22

1 reference

Europe PubMed Central

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27 September 2017

Fubao Wang

24

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Richard A. Hampton

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

Jing Z. Zhao

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

Stephen W. Jarantow

10

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

Kevin R. Scott

14

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

John E. Fisher

15

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

Alfred A. Reszka

18

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

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publication date

7 October 2010

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27 September 2017

full work available at URL

http://www.jbc.org/article/S0021925820605452/pdf

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20929859/pdf/?tool=EBI

Portable Document Format

online access status

content deliverer

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

http://intl.jbc.org/cgi/content/abstract/285/51/40135

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20929859/?tool=EBI

online access status

content deliverer

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

https://europepmc.org/articles/PMC3000996

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

https://europepmc.org/articles/PMC3000996?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

https://doi.org/10.1074/jbc.m110.166892

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20929859

29 July 2024

https://api.elsevier.com/content/article/PII:S0021925820605452?httpAccept=text/xml

1 reference

10.1074/JBC.M110.166892

https://api.crossref.org/works/10.1074/JBC.M110.166892

29 July 2024

https://api.elsevier.com/content/article/PII:S0021925820605452?httpAccept=text/plain

1 reference

10.1074/JBC.M110.166892

https://api.crossref.org/works/10.1074/JBC.M110.166892

29 July 2024

https://syndication.highwire.org/content/doi/10.1074/jbc.M110.166892

1 reference

10.1074/JBC.M110.166892

https://api.crossref.org/works/10.1074/JBC.M110.166892

29 July 2024

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

285

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

51

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

40135-40147

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

Wnt proteins promote bone regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Modulation of Wnt signaling influences fracture repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Dickkopf-1 as a potential therapeutic target in Paget's disease of bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Promising bone-related therapeutic targets for rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Dickkopf-1: a suitable target for the management of myeloma bone disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Future therapeutic targets in osteoporosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Translating insights from development into regenerative medicine: the function of Wnts in bone biology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

The role of Dickkopf-1 in bone development, homeostasis, and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Bone mass is inversely proportional to Dkk1 levels in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

LRP6 mutation in a family with early coronary disease and metabolic risk factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Function and biological roles of the Dickkopf family of Wnt modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Wnt signaling: a key regulator of bone mass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Determination of protein-derived epitopes by mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Wnt signaling in disease and in development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

LRP5 and Wnt signaling: a union made for bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

WNT and beta-catenin signalling: diseases and therapies

1 reference

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20 June 2018

BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

High bone mass in mice expressing a mutant LRP5 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Control of osteoblast function and regulation of bone mass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

High bone density due to a mutation in LDL-receptor-related protein 5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Colipase: structure and interaction with pancreatic lipase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

Cloning of a novel member of the low-density lipoprotein receptor family

1 reference

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20 June 2018

Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library

1 reference

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20 June 2018

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000996

20 June 2018

The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2

1 reference

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20 June 2018

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

1 reference

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20 June 2018

Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.166892

21 January 2018

Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.166892

21 January 2018

Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis

1 reference

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21 January 2018

Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.

1 reference

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21 January 2018

IgG2m4, an engineered antibody isotype with reduced Fc function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.166892

21 January 2018

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/20929859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dickkopf-1 is a master regulator of joint remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20929859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibody pharmacokinetics and pharmacodynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20929859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.166892

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

27 September 2017

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