(Q30473178)

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The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism.

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12 December 2019

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism (English)

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12 December 2019

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Parkinson's disease

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David S Cassarino

1

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12 December 2019

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J K Parks

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12 December 2019

W D Parker

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12 December 2019

J P Bennett

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12 December 2019

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1 January 1999

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12 December 2019

Biochimica et Biophysica Acta

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12 December 2019

1453

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12 December 2019

1

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12 December 2019

49-62

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12 December 2019

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1 reference

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7 January 2021

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The mitochondrial permeability transition.

1 reference

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The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal

1 reference

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The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1 reference

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Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial-generated reactive oxygen species.

1 reference

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Effect of inorganic phosphate concentration on the nature of inner mitochondrial membrane alterations mediated by Ca2+ ions. A proposed model for phosphate-stimulated lipid peroxidation.

1 reference

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Mechanisms by which mitochondria transport calcium

1 reference

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The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

1 reference

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Exposure to the parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP+) and nitric oxide simultaneously causes cyclosporin A-sensitive mitochondrial calcium efflux and depolarisation

1 reference

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7 January 2021

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On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide.

1 reference

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7 January 2021

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Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.

1 reference

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7 January 2021

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Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state

1 reference

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Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition.

1 reference

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7 January 2021

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Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

1 reference

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Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2+: correlation with mitochondrial permeability transition

1 reference

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Origin and functional consequences of the complex I defect in Parkinson's disease

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Point mutations of mitochondrial genome in Parkinson's disease

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Abnormalities of the electron transport chain in idiopathic Parkinson's disease

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Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

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Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson's disease

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Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease

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Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease

1 reference

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7 January 2021

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Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

1 reference

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7 January 2021

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Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease

1 reference

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7 January 2021

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Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

1 reference

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7 January 2021

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Mechanism of the neurotoxicity of MPTP. An update

1 reference

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7 January 2021

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Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1 reference

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7 January 2021

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MPTP-induced oxidative stress and neurotoxicity are age-dependent: evidence from measures of reactive oxygen species and striatal dopamine levels

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

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inferred from DOI database lookup

Mitochondrial respiratory chain inhibitors induce apoptosis.

1 reference

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7 January 2021

based on heuristic

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Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Bioenergetic and oxidative stress in neurodegenerative diseases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Parkinson's disease and free radicals. Mechanism of neurodegeneration and neuroprotection

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial control of nuclear apoptosis.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial permeability transition is a central coordinating event of apoptosis

1 reference

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7 January 2021

based on heuristic

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Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function.

1 reference

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based on heuristic

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Ca2+ and cell death

1 reference

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7 January 2021

based on heuristic

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Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor

1 reference

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Release of cytochrome c from liver mitochondria during permeability transition.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial Permeability Transition in the Central Nervous System: Induction by Calcium Cycling‐Dependent and ‐Independent Pathways

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Enzymatic properties of the inner and outer membranes of rat liver mitochondria

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Preparation of synaptic and nonsynaptic mitochondria from mammalian brain

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The peptide mastoparan is a potent facilitator of the mitochondrial permeability transition

1 reference

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7 January 2021

based on heuristic

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Molecular proportion of the fixed cytochrome components of the respiratory chain of Keilin-Hartree particles and beef heart mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Studies on the toxicity of 1-methyl-4-phenylpyridinium ion (MPP+) against mitochondria of mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: inhibition of NAD-linked substrate oxidation by its metabolite, 1-methyl-4-phenylpyridinium

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Reduction of MPP(+)-induced hydroxyl radical formation and nigrostriatal MPTP toxicity by inhibiting nitric oxide synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

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Comparison of the membrane-related effects of cytarabine and other agents on model membranes

1 reference

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7 January 2021

based on heuristic

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Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Intracranial microdialysis of salicylic acid to detect hydroxyl radical generation through dopamine autooxidation in the caudate nucleus: effects of MPP+

1 reference

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7 January 2021

based on heuristic

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ca(2+)-triggered membrane permeability transition in deenergized mitochondria from rat liver

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of Ca 2+ release from mitochondria by the oxidation-reduction state of pyridine nucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2898%2900083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationships between the NAD(P) redox state, fatty acid oxidation, and inner membrane permeability in rat liver mitochondria

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Calcium-ion transport by intact Ehrlich ascites-tumour cells. Role of respiratory substrates, Pi and temperature

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Butylated hydroxytoluene and inorganic phosphate plus Ca2+ increase mitochondrial permeability via mutually exclusive mechanisms

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Selective inhibition of the mitochondrial permeability transition pore at the oxidation-reduction sensitive dithiol by monobromobimane

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of a Caspase‐3‐Like Cysteine Protease in 1‐Methyl‐4‐Phenylpyridinium‐Mediated Apoptosis of Cultured Cerebellar Granule Neurons

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0925-4439(98)00083-0

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9989245%20AND%20SRC:MED&resulttype=core&format=json

12 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9989245%20AND%20SRC:MED&resulttype=core&format=json

12 December 2019

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