(Q29812939)

Synaptotagmin 1/2

1 reference

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Synaptotagmin

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

16 July 2018

Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21521&geneProductId=UniProtKB:P21521

phosphatidylserine binding

1 reference

16 July 2018

Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21521&geneProductId=UniProtKB:P21521

calcium ion binding

2 references

protein binding

3 references

8 April 2019

The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin.

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

calcium-dependent phospholipid binding

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21521&geneProductId=UniProtKB:P21521

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21521&geneProductId=UniProtKB:P21521

16 July 2018

16 July 2018

Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21521&geneProductId=UniProtKB:P21521

syntaxin binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

clathrin binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

protein homodimerization activity

1 reference

8 April 2019

Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

1 reference

8 April 2019

calcium ion binding

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

calcium-dependent phospholipid binding

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

8 April 2019

Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

cell component

plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

synaptic vesicle

A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

8 April 2019

Discrete residues in the c(2)b domain of synaptotagmin I independently specify endocytic rate and synaptic vesicle size

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

1 reference

8 April 2019

integral component of synaptic vesicle membrane

NAS

1 reference

8 April 2019

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

NAS

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

1 reference

8 April 2019

synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

1 reference

8 April 2019

axon

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

dense core granule

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

exocytic vesicle

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

chemical synaptic transmission

biological process

1 reference

8 April 2019

Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

neurotransmitter secretion

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

NAS

8 April 2019

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

regulation of pole plasm oskar mRNA localization

1 reference

8 April 2019

Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

larval locomotory behavior

1 reference

8 April 2019

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

synaptic vesicle exocytosis

1 reference

16 July 2018

A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21521&geneProductId=UniProtKB:P21521

vesicle-mediated transport

Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21521&geneProductId=UniProtKB:P21521

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21521&geneProductId=UniProtKB:P21521

16 July 2018

Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21521&geneProductId=UniProtKB:P21521

regulation of calcium ion-dependent exocytosis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

positive regulation of vesicle fusion

1 reference

8 April 2019

Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

synaptic vesicle endocytosis

calcium ion-regulated exocytosis of neurotransmitter

1 reference

16 July 2018

Characterization of the role of the Synaptotagmin family as calcium sensors in facilitation and asynchronous neurotransmitter release

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21521&geneProductId=UniProtKB:P21521

regulation of synapse structure or activity

1 reference

8 April 2019

Altered synaptic development and active zone spacing in endocytosis mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

rhythmic synaptic transmission

1 reference

8 April 2019

Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

regulation of neuromuscular synaptic transmission

1 reference

8 April 2019

Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

regulation of dopamine secretion

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

vesicle-mediated transport

Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

calcium-ion regulated exocytosis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

calcium ion-regulated exocytosis of neurotransmitter

cellular response to calcium ion

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

clathrin-dependent synaptic vesicle endocytosis

1 reference

8 April 2019

Discrete residues in the c(2)b domain of synaptotagmin I independently specify endocytic rate and synaptic vesicle size

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21521

1 reference

C2 domain

1 reference