(Q29805684)

English

Gamma-secretase subunit aph-1 CELE_VF36H2L.1

protein found in Caenorhabditis elegans

aph-1
Gamma-secretase subunit aph-1

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Statements

1 reference

5 December 2018

Gamma-secretase subunit Aph-1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O45876

found in taxon

Caenorhabditis elegans

1 reference

5 December 2018

1 reference

5 December 2018

endoplasmic reticulum

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IBA

integral component of plasma membrane

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IBA

membrane

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IEA

biological process

Notch signaling pathway

determination method or standard

3 references

16 July 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O45876&geneProductId=UniProtKB:O45876

determination method or standard

IMP

retrieved

16 July 2018

stated in

Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?protein=O45876&geneProductId=UniProtKB:O45876

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O45876&geneProductId=UniProtKB:O45876

determination method or standard

IEA

Notch receptor processing

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IBA

embryo development ending in birth or egg hatching

determination method or standard

IMP

1 reference

retrieved

1 January 2018

stated in

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IMP

protein localization to cell surface

determination method or standard

IMP

positive regulation of catalytic activity

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IEA

cell fate commitment

determination method or standard

IGI

1 reference

retrieved

1 January 2018

stated in

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IGI

embryonic morphogenesis

determination method or standard

IMP

1 reference

retrieved

1 January 2018

stated in

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IMP

oocyte development

determination method or standard

IMP

1 reference

retrieved

1 January 2018

stated in

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IMP

pharynx development

determination method or standard

IMP

1 reference

retrieved

1 January 2018

stated in

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IMP

cell fate commitment involved in pattern specification

determination method or standard

IMP

1 reference

retrieved

1 January 2018

stated in

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IMP

Notch signaling pathway

determination method or standard

4 references

1 January 2018

Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IMP

retrieved

1 January 2018

stated in

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IEA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O45876

determination method or standard

IBA

Identifiers

1 reference

14 December 2018

1 reference

5 December 2018

1 reference

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