(Q29870999)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

title

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

Dickkopf WNT signaling pathway inhibitor 1

18 February 2020

main subject

1 reference

Clusterin

1 reference

Amyloid beta precursor protein

1 reference

microtubule associated protein tau

1 reference

catenin beta 1

1 reference

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

1 reference

Dickkopf WNT signaling pathway inhibitor 1

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

R Al-Shawi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

B Malik

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

C Hooper

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

C Fernandes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

K Lin

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

R Wroe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

A W M To

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

M Causevic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

A Usardi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

M Robinson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

C H Reynolds

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

C Bazenet

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

J Stephenson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

S Kellie

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

language of work or name

English

0 references

publication date

20 November 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

page(s)

88-98

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

18 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Rational siRNA design for RNA interference

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Early Growth Response 1 (Egr-1) Regulates Phosphorylation of Microtubule-associated Protein Tau in Mammalian Brain

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Functional and structural diversity of the human Dickkopf gene family

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling

10 May 2017

1 reference

https://api.crossref.org/works/10.1038%2FMP.2012.163

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

10 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Discovering regulatory and signalling circuits in molecular interaction networks

12 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

12 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Novel mutants of NAB corepressors enhance activation by Egr transactivators

12 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

12 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling

12 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

GSK3 and Alzheimer's Disease: Facts and Fiction….

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Control of synapse development and plasticity by Rho GTPase regulatory proteins.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Plasma clusterin and the risk of Alzheimer disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Conformations and biological activities of amyloid beta peptide 25-35.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

p53 is regulated by and regulates members of the gamma-secretase complex

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Cystatin C protects neuronal cells from amyloid-beta-induced toxicity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Alzheimer disease: New light on an old CLU.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Genetic control of human brain transcript expression in Alzheimer disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

A novel activity of the Dickkopf-1 amino terminal domain promotes axial and heart development independently of canonical Wnt inhibition

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Noncanonical Wnt signaling and neural polarity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Presenilin 1 independently regulates beta-catenin stability and transcriptional activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Clusterin: a role in cell survival in the face of apoptosis?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Alzheimer's disease and tau proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

An integrated genetics approach for identifying protein signal pathways of Alzheimer's disease

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Gene expression profiling in the adult Down syndrome brain.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

Expression of Fos, Jun, and Krox family proteins in Alzheimer's disease.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873038

The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23164821

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/MP.2012.163

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

18 February 2020

1009234054

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

23164821

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23164821%20AND%20SRC:MED&resulttype=core&format=json