(Q29547667)

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

scientific article (publication date: 20 November 1998)

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage (English)

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PubMed

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9822382

23 April 2017

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Vogelstein B

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23 April 2017

Kinzler KW

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9822382

23 April 2017

Sedivy JM

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9822382

23 April 2017

Bunz F

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Dutriaux A

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Lengauer C

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Waldman T

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Zhou S

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Brown JP

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language of work or name

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publication date

20 November 1998

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9822382

23 April 2017

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volume

282

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issue

5393

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page(s)

1497-501

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describes a project that uses

p53HCT116

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cites work

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p53, the cellular gatekeeper for growth and division

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Abnormal centrosome amplification in the absence of p53.

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Identification of a nuclear-specific cyclophilin which interacts with the proteinase inhibitor eglin c

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Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity

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Universal control mechanism regulating onset of M-phase

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p53: puzzle and paradigm

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Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression

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Inhibition of cyclin-dependent kinases by p21

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Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2.

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Regulatory roles of the nuclear envelope

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Development of apoptosis and polyploidy in human lymphoblast cells as a function of position in the cell cycle at the time of irradiation

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Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

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Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

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Radiation-induced cell cycle arrest compromised by p21 deficiency

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A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein.

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Role of phosphorylation in p34cdc2 activation: identification of an activating kinase

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Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

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Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition

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Qualifying for the license to replicate

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Checkpoint pathways come of age.

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Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

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Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

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Geminin, an inhibitor of DNA replication, is degraded during mitosis

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p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

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