(Q28610652)

3 February 2017

title

Vav2 is an activator of Cdc42, Rac1, and RhoA (English)

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3 February 2017

K. Abe

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3 February 2017

K. L. Rossman

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3 February 2017

B. Liu

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3 February 2017

K. D. Ritola

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3 February 2017

D. Chiang

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3 February 2017

S. L. Campbell

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3 February 2017

K. Burridge

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3 February 2017

C. J. Der

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3 February 2017

language of work or name

English

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publication date

7 April 2000

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Journal of Biological Chemistry

3 February 2017

published in

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3 February 2017

volume

275

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3 February 2017

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3 February 2017

page(s)

10141–10149

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The Dbl family of oncogenes

3 February 2017

cites work

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

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An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

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Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun

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Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors

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The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor

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A role for Rac in Tiam1-induced membrane ruffling and invasion

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Lck regulates Vav activation of members of the Rho family of GTPases

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

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Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

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Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

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Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

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CDC42 and FGD1 cause distinct signaling and transforming activities

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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

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NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

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Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1

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Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential

21 January 2018

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Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity

21 January 2018

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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

21 January 2018

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Association between GTPase activators for Rho and Ras families.

21 January 2018

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Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

21 January 2018

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Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

21 January 2018

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Biological assays for Ras transformation

21 January 2018

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Transcriptional activation analysis of oncogene function

21 January 2018

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Ras-mediated transcription activation: analysis by transient cotransfection assays

21 January 2018

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JNK is involved in signal integration during costimulation of T lymphocytes.

21 January 2018

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Purification of recombinant Rho/Rac/G25K from Escherichia coli.

21 January 2018

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Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

21 January 2018

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Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using fluorescence spectroscopy.

21 January 2018

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

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Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus

21 January 2018

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Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

21 January 2018

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A novel regulator of p21-activated kinases

21 January 2018

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