(Q28534771)

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Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer

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Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer (English)

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pancreatic cancer

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Rachana N Pradhan

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Rachana N Pradhan

2

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Saikat Chowdhury

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Saikat Chowdhury

1

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Ram Rup Sarkar

3

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2013

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8

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7

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e69132

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Creative Commons Attribution 4.0 International

23 July 2013

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April 2022 Public Data File from Crossref

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Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway

1 reference

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19 March 2017

A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion

1 reference

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19 March 2017

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3720582

19 March 2017

Structural and functional analysis of cellular networks with CellNetAnalyzer

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19 March 2017

Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer

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19 March 2017

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

1 reference

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19 March 2017

FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells

1 reference

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19 March 2017

PTCH mutations: distribution and analyses

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19 March 2017

Hedgehog signaling pathway and gastric cancer

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19 March 2017

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2

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19 March 2017

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

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19 March 2017

Combined activities of hedgehog signaling inhibitors regulate pancreas development

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19 March 2017

Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung

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Targeting RAS signalling pathways in cancer therapy

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19 March 2017

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

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Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1

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19 March 2017

Cooperative E-box regulation of human GLI1 by TWIST and USF

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19 March 2017

Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells

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19 March 2017

Gli regulation by the opposing activities of fused and suppressor of fused

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19 March 2017

ras oncogenes in human cancer: a review

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7 April 2017

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

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7 April 2017

Hedgehog pathway inhibition and the race against tumor evolution

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29 September 2017

Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations

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29 September 2017

Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma.

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29 September 2017

Molecular pathways: the hedgehog signaling pathway in cancer

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29 September 2017

Targeting the Hedgehog signaling pathway for cancer therapy

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29 September 2017

Activation of the Sonic Hedgehog pathway in thyroid neoplasms and its potential role in tumor cell proliferation

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29 September 2017

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer

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29 September 2017

SNAI1 is involved in the proliferation and migration of glioblastoma cells

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29 September 2017

ArrayExpress update--an archive of microarray and high-throughput sequencing-based functional genomics experiments

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29 September 2017

Logic-based models for the analysis of cell signaling networks

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29 September 2017

Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell lines

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29 September 2017

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

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29 September 2017

FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.

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29 September 2017

The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data

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29 September 2017

Hedgehog signaling in development and cancer.

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29 September 2017

Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal

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29 September 2017

Identifying gene-disease associations using centrality on a literature mined gene-interaction network

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29 September 2017

Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis

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29 September 2017

Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas

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29 September 2017

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

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29 September 2017

Hedgehog signaling.

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29 September 2017

Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review).

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29 September 2017

The hedgehog signaling pathway in cancer

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29 September 2017

Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

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29 September 2017

Hedgehog signalling: how to get from Smo to Ci and Gli.

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29 September 2017

A methodology for the structural and functional analysis of signaling and regulatory networks

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29 September 2017

Cancer: a Systems Biology disease

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29 September 2017

GLI transcription factors: mediators of oncogenic Hedgehog signalling

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29 September 2017

TWIST is expressed in human gliomas and promotes invasion

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29 September 2017

Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1.

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29 September 2017

Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment

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29 September 2017

Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer

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29 September 2017

Hedgehog signaling promotes prostate xenograft tumor growth

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29 September 2017

Regulation of Hedgehog signaling: a complex story

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29 September 2017

Short- and long-range effects of Sonic hedgehog in limb development

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29 September 2017

The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster

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29 September 2017

Gli and hedgehog in cancer: tumours, embryos and stem cells.

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29 September 2017

Hedgehog-Gli signalling and the growth of the brain.

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29 September 2017

RAS inhibitors: potential for cancer therapeutics

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29 September 2017

Transcriptional activity of GLI1 is negatively regulated by protein kinase A.

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29 September 2017

Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas

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29 September 2017

Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma

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29 September 2017

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.

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2 June 2018

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

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2 June 2018

Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function

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2 June 2018

Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells

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2 June 2018

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3720582

2 June 2018

Patching the gaps in Hedgehog signalling

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21 January 2018

Signal dynamics in Sonic hedgehog tissue patterning

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21 January 2018

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

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21 January 2018

Medulloblastoma growth inhibition by hedgehog pathway blockade

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21 January 2018

An application programming interface for CellNetAnalyzer

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21 January 2018

Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells

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21 January 2018

Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme

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21 January 2018

The effect of cyclin D expression on cell proliferation in human gliomas.

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21 January 2018

Analysis of weighted networks.

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21 January 2018

Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain

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21 January 2018

Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer.

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27 November 2018

Robustness of the Drosophila segment polarity network to transient perturbations.

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27 November 2018

The small world inside large metabolic networks.

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27 November 2018

Prognostic and pathologic significance of quantitative protein expression profiling in human gliomas.

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27 November 2018

Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.

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27 November 2018

Expression of osteopontin in human glioma. Its correlation with the malignancy

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27 November 2018

Using process diagrams for the graphical representation of biological networks

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23935937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the Hedgehog pathway in cancer

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0069132

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2013PLoSO...869132C

0 references

release_qrz7hltcnfdmldaf6vnxqc7ht4

1 reference

https://api.fatcat.wiki/v0/release/qrz7hltcnfdmldaf6vnxqc7ht4

24 November 2022

based on heuristic

mapped directly with Wikidata item

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