(Q28589263)

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

title

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

BCL2-like 11 (apoptosis facilitator)

1 January 2020

main subject

1 reference

B cell leukemia/lymphoma 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Fred D Finkelman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Sara Wojciechowski

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Pulak Tripathi

series ordinal

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Tristan Bourdeau

series ordinal

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Luis Acero

series ordinal

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

language of work or name

English

0 references

publication date

25 June 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental Medicine

1 January 2020

published in

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

volume

204

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

page(s)

1665-1675

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Viral immune evasion due to persistence of activated T cells without effector function

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Bcl-2 and Bax function independently to regulate cell death

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Phenotypic analysis of antigen-specific T lymphocytes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

IL-7 promotes the transition of CD4 effectors to persistent memory cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Interleukin 7 regulates the survival and generation of memory CD4 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Cytokine control of memory T-cell development and survival

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

IL-7 is critical for homeostatic proliferation and survival of naive T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Cytokine-induced survival of activated T cells in vitro and in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Vaccination against persistent viral infection exacerbates CD4+ T-cell-mediated immunopathological disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

The effect of in vivo IL-7 deprivation on T cell maturation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

Control of homeostasis of CD8+ memory T cells by opposing cytokines.

3 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

OX40 and Bcl-xL promote the persistence of CD8 T cells to recall tumor-associated antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

Ablation of CD8 and CD4 T cell responses by high viral loads

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070618

Bystander virus infection prolongs activated T cell survival

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118628

CD28 costimulation prevents cell death during primary T cell activation

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/17591857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17591857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bax deficiency partially corrects interleukin-7 receptor alpha deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/17591857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20070618

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17591857%20AND%20SRC:MED&resulttype=core&format=json