(Q28559439)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q63120

Canalicular multispecific organic anion transporter 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q63120

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q63120

AAA proteins

1 reference

ABC transporter-like, protein family

1 reference

ABC transporter type 1, transmembrane domain, protein family

1 reference

ABC transporter, conserved site, protein family

1 reference

1 reference

17 November 2021

1 reference

17 November 2021

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

1 reference

9 May 2019

protein binding

1 reference

9 May 2019

NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

ATPase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

1 reference

9 May 2019

protein domain specific binding

1 reference

9 May 2019

Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

transmembrane transporter activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

1 reference

9 May 2019

cell component

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

1 reference

9 May 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

9 May 2019

Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

IBA

apical plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

5 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

9 May 2019

NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

9 May 2019

Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

IBA

brush border membrane

1 reference

9 May 2019

Function of multidrug resistance-associated protein 2 in acute hepatic failure rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

intercellular canaliculus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

cell surface

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

xenobiotic transmembrane transport

biological process

1 reference

9 May 2019

Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

response to oxidative stress

1 reference

9 May 2019

Oxidative stress and Mrp2 internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

female pregnancy

1 reference

9 May 2019

The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

response to heat

1 reference

9 May 2019

Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

mercury ion transport

1 reference

9 May 2019

MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

organic anion transport

TAS

1 reference

9 May 2019

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

canalicular bile acid transport

TAS

1 reference

9 May 2019

Quantification of drug transport function across the multiple resistance-associated protein 2 (Mrp2) in rat livers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

prostaglandin transport

1 reference

9 May 2019

Multidrug resistance associated protein 2 mediates transport of prostaglandin E2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

antibiotic metabolic process

1 reference

9 May 2019

Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

cellular chloride ion homeostasis

1 reference

9 May 2019

Mrp2 modulates the activity of chloride channels in isolated hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

response to methotrexate

1 reference

9 May 2019

Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

response to lipopolysaccharide

1 reference

9 May 2019

Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

response to glucagon

1 reference

9 May 2019

Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

response to estrogen

1 reference

9 May 2019

Estradiol-17β-D-glucuronide induces endocytic internalization of Bsep in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

response to arsenic-containing substance

1 reference

9 May 2019

Effects of MRP2-GSH cotransport system on hepatic arsenic metabolism in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

response to steroid hormone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

1 reference

9 May 2019

thyroid hormone transport

1 reference

9 May 2019

Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

cellular response to lipopolysaccharide

1 reference

9 May 2019

Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

cellular response to interleukin-1

1 reference

9 May 2019

Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

cellular response to interleukin-6

1 reference

9 May 2019

Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

cellular response to tumor necrosis factor

1 reference

9 May 2019

Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

cellular response to dexamethasone stimulus

1 reference

9 May 2019

Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

response to antineoplastic agent

1 reference

9 May 2019

Effect of 5-fluorouracil treatment on SN-38 absorption from intestine in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

benzylpenicillin metabolic process

1 reference

9 May 2019

Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120