(Q28307422)

object named as

Bradley T Hyman

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author name string

Tiago Fleming Outeiro

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Eirene Kontopoulos

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Stephen M Altmann

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Irina Kufareva

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Katherine E Strathearn

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Allison M Amore

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Catherine B Volk

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Michele M Maxwell

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Jean-Christophe Rochet

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Pamela J McLean

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Anne B Young

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Mel B Feany

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Aleksey G Kazantsev

α-Synuclein in Lewy bodies

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language of work or name

English

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publication date

27 July 2007

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published in

Science

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volume

317

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issue

5837

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page(s)

516-9

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cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

alpha-Synuclein locus triplication causes Parkinson's disease

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

The Sir2 family of protein deacetylases

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1143780

A Drosophila model of Parkinson's disease

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

Opposing activities protect against age-onset proteotoxicity

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1143780