(Q28303740)

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Didier Belorgey

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Lynda K Sharp

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David A Lomas

Journal of Biological Chemistry

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language of work or name

English

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publication date

8 April 2005

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published in

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volume

280

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issue

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page(s)

13735-41

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cites work

Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Association between conformational mutations in neuroserpin and onset and severity of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Inhibitory conformation of the reactive loop of alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Alpha1-antitrypsin deficiency--a model for conformational diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

21 January 2018

Conformational disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Mutations which impede loop/sheet polymerization enhance the secretion of human alpha 1-antitrypsin deficiency variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Plasminogen-activator inhibitor type 2 (PAI-2) is a spontaneously polymerising SERPIN. Biochemical characterisation of the recombinant intracellular and extracellular forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

A redox-sensitive loop regulates plasminogen activator inhibitor type 2 (PAI-2) polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Latent alpha1-antichymotrypsin. A molecular explanation for the inactivation of alpha1-antichymotrypsin in chronic bronchitis and emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Preparative induction and characterization of L-antithrombin: a structural homologue of latent plasminogen activator inhibitor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Engineering plasminogen activator inhibitor 1 mutants with increased functional stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

The molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Lysine 156promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Structural basis of latency in plasminogen activator inhibitor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Biological implications of a 3 A structure of dimeric antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Interactions causing the kinetic trap in serpin protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

The Low Density Lipoprotein Receptor-related Protein Modulates Protease Activity in the Brain by Mediating the Cellular Internalization of Both Neuroserpin and Neuroserpin-Tissue-type Plasminogen Activator Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Cognitive deficits associated with a recently reported familial neurodegenerative disease: familial encephalopathy with neuroserpin inclusion bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

α1-Antitrypsin Polymerisation Can Occur by both Loop A and C Sheet Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413282200

release_k5vhzczf4zcgbi6uy3ldqpsz4u

21 January 2018

Identifiers

DOI

10.1074/JBC.M413282200

0 references

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/k5vhzczf4zcgbi6uy3ldqpsz4u