(Q28377996)

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J Chen

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J Peng

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J Yuan

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G D Prestwich

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J S Brugge

Journal of Biological Chemistry

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language of work or name

English

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publication date

31 December 1999

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published in

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volume

274

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issue

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page(s)

37893-900

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cites work

Phosphoinositide 3-kinases: A conserved family of signal transducers

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The role of phosphoinositide 3-kinase lipid products in cell function

21 January 2018

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Downstream signalling events regulated by phosphatidylinositol 3-kinase activity

21 January 2018

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Using structure to define the function of phosphoinositide 3‐kinase family members

21 January 2018

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EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

21 January 2018

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Inositol lipid 5-phosphatases--traffic signals and signal traffic.

21 January 2018

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A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate

21 January 2018

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Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules

21 January 2018

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

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The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

21 January 2018

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Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

21 January 2018

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Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength

21 January 2018

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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

21 January 2018

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Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

21 January 2018

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Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking

21 January 2018

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

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Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1

21 January 2018

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Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase

21 January 2018

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Regulation of chemotaxis by the platelet-derived growth factor receptor-beta

21 January 2018

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Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

21 January 2018

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Regulation of inositol lipid kinases by Rho and Rac.

21 January 2018

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

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Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

21 January 2018

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The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene

21 January 2018

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Molecular genetics of childhood leukemias

21 January 2018

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

21 January 2018

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Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion

21 January 2018

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

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A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

21 January 2018

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

21 January 2018

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Signalling through the lipid products of phosphoinositide-3-OH kinase

21 January 2018

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Protein kinase C. Seeing two domains

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Epstein-Barr Virus EBNA-2 gene expression enhances lymphotoxin production by B lymphocytes.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Geminin, an inhibitor of DNA replication, is degraded during mitosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

cDNA cloning of porcine p42IP4, a membrane-associated and cytosolic 42 kDa inositol(1,3,4,5)tetrakisphosphate receptor from pig brain with similarly high affinity for phosphatidylinositol (3,4,5)P3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Identification of centaurin-α1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Evidence that a phosphatidylinositol 3,4,5-trisphosphate-binding protein can function in nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Recognition and specificity in protein tyrosine kinase-mediated signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Specific detection of phosphatidylinositol 3,4,5-trisphosphate binding proteins by the PIP3 analogue beads: an application for rapid purification of the PIP3 binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.37893