(Q28207854)

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Douglas J Pitera

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Sydnor T Withers

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Jack D Newman

Paclitaxel (Taxol): a success story with valuable lessons for natural product drug discovery and development

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language of work or name

English

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publication date

July 2003

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796-802

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cites work

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7 January 2021

Current status of artemisinin and its derivatives as antimalarial drugs

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7 January 2021

Total Synthesis of Baccatin III and Taxol

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7 January 2021

Medical need, scientific opportunity and the drive for antimalarial drugs

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7 January 2021

Artemisinin and derivatives: the future for malaria treatment?

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7 January 2021

Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: proof for the existence of chemotypes

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7 January 2021

Taxol: biosynthesis, molecular genetics, and biotechnological applications

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7 January 2021

Irofulven, a novel inhibitor of DNA synthesis, in metastatic renal cell cancer

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7 January 2021

The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways.

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7 January 2021

Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein

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7 January 2021

Genetic and physiological relationships among the miaA gene, 2-methylthio-N6-(delta 2-isopentenyl)-adenosine tRNA modification, and spontaneous mutagenesis in Escherichia coli K-12.

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7 January 2021

Precursor balancing for metabolic engineering of lycopene production in Escherichia coli

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7 January 2021

Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli

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7 January 2021

Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production

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7 January 2021

Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L

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7 January 2021

The in vivo synthesis of plant sesquiterpenes by Escherichia coli

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7 January 2021

Construction and characterization of Escherichia coli disruptants defective in the yaeM gene.

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7 January 2021

State of the art of the production of the antimalarial compound artemisinin in plants

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7 January 2021

Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis

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7 January 2021

Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin

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7 January 2021

Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis

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7 January 2021

Codon optimization of the gene encoding a domain from human type 1 neurofibromin protein results in a threefold improvement in expression level in Escherichia coli

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7 January 2021

Combinatorial biosynthesis of carotenoids in a heterologous host: a powerful approach for the biosynthesis of novel structures.

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7 January 2021

Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol

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7 January 2021

Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase

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7 January 2021

Expression of prokaryotic 1-deoxy-D-xylulose-5-phosphatases in Escherichia coli increases carotenoid and ubiquinone biosynthesis

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7 January 2021

Engineered isoprenoid pathway enhances astaxanthin production in Escherichia coli

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7 January 2021

Molecular structure and enzymatic function of lycopene cyclase from the cyanobacterium Synechococcus sp strain PCC7942.

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7 January 2021

Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast.

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7 January 2021

Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettes

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7 January 2021

Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter

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7 January 2021

Analysis and purification of phosphorylated isoprenoids by reversed-phase HPLC

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7 January 2021