(Q28267699)

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G van der Horst

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H Cheung

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C van den Hoogen

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G van der Pluijm

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P Ten Dijke

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

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language of work or name

English

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publication date

4 March 2010

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1351-61

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cites work

1 reference

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Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

21 April 2017

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Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

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Smad transcription factors

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

21 April 2017

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New insights into TGF-beta-Smad signalling

21 April 2017

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

21 April 2017

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Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

21 April 2017

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High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene

21 April 2017

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TGF-beta and BMP7 interactions in tumour progression and bone metastasis

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Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer

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Osteotropic cancers: from primary tumor to bone

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The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells

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Determination of TGFbeta1 protein level in human primary breast cancers and its relationship with survival

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Smad3 is a key nonredundant mediator of transforming growth factor beta signaling in Nme mouse mammary epithelial cells

21 January 2018

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Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line.

21 January 2018

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A multigenic program mediating breast cancer metastasis to bone

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Molecular biology of bone metastasis

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Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts.

21 January 2018

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Transforming growth factor-beta signaling in cancer invasion and metastasis

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Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase

21 January 2018

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Invasion and metastasis of a mammary tumor involves TGF-beta signaling

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Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

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TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways

21 January 2018

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An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments.

21 January 2018

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Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis

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Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

21 January 2018

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Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis

21 January 2018

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Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression

21 January 2018

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TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

21 January 2018

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The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice

21 January 2018

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Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines

21 January 2018

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Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.

21 January 2018

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TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

21 January 2018

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Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells

21 January 2018

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A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.426

TGFβ-1 regulation of VEGF production by breast cancer cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.426

Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor- Type I Receptor Kinase In vivo

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.426

Elevated plasma levels of transforming growth factor-beta 1 (TGF-beta 1) in patients with advanced breast cancer: association with disease progression

31 March 2020

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Microarray analysis of gene expression during epithelial-mesenchymal transformation

31 March 2020

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Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

31 March 2020

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Serum levels of transforming growth factor beta1 in patients with breast cancer

31 March 2020

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Monitoring metastatic behavior of human tumor cells in mice with species-specific polymerase chain reaction: elevated expression of angiogenesis and bone resorption stimulators by breast cancer in bone metastases

31 March 2020

1 reference

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