(Q28267119)

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Georg Lentzen

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Michael Sierks

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Chan Beum Park

Assembly of amyloid protofibrils via critical oligomers--a novel pathway of amyloid formation

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language of work or name

English

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publication date

29 August 2005

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published in

FEBS Letters

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volume

579

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issue

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page(s)

4775-80

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cites work

1 reference

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Therapeutic strategies for Alzheimer's disease

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Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

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The environmental dependency of protein folding best explains prion and amyloid diseases

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Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

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The process of amyloid-like fibril formation by methionine aminopeptidase from a hyperthermophile, Pyrococcus furiosus

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Amyloid fibrils from muscle myoglobin

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Peptide aggregation in neurodegenerative disease

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Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation

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Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

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Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity

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Organic solutes from thermophiles and hyperthermophiles

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Inhibition of insulin amyloid formation by small stress molecules

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1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. A novel cyclic amino acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira

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Compatible-solute-supported periplasmic expression of functional recombinant proteins under stress conditions

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Comparative study of the thermostabilizing properties of mannosylglycerate and other compatible solutes on model enzymes

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Extrinsic protein stabilization by the naturally occurring osmolytes beta-hydroxyectoine and betaine

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High survival and stability rates of Escherichia coli dried in hydroxyectoine

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

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Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

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A possible role for pi-stacking in the self-assembly of amyloid fibrils

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Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

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Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy.

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Toward understanding insulin fibrillation

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Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism

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Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

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Impact of compatible solutes on the mechanical properties of fibronectin: a single molecule analysis

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