(Q28253993)

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Microtubules as a target for anticancer drugs

scientific article published in April 2004

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Europe PubMed Central

Microtubules as a target for anticancer drugs (English)

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Mary Ann Jordan

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Leslie Wilson

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April 2004

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Nature Reviews Cancer

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4

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4

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253-65

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Direct Analysis of Tubulin Expression in Cancer Cell Lines by Electrospray Ionization Mass Spectrometry

1 reference

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The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization

1 reference

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31 March 2020

Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics.

1 reference

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31 March 2020

The oncoprotein 18/stathmin family of microtubule destabilizers

1 reference

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31 March 2020

The interaction of TOGp with microtubules and tubulin

1 reference

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31 March 2020

Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin

1 reference

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31 March 2020

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

1 reference

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31 March 2020

Tubulin/microtubules: still a promising target for new chemotherapeutic agents

1 reference

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31 March 2020

Microtubule dynamics: treadmilling comes around again

1 reference

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31 March 2020

Dynamic instability of microtubule growth

1 reference

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31 March 2020

Opposite end assembly and disassembly of microtubules at steady state in vitro

1 reference

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31 March 2020

Microtubule treadmilling: what goes around comes around

1 reference

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31 March 2020

Microtubule treadmilling in vivo

1 reference

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Sustained Microtubule Treadmilling in Arabidopsis Cortical Arrays

1 reference

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Rapid treadmilling of brain microtubules free of microtubule-associated proteins in vitro and its suppression by tau

1 reference

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31 March 2020

Kinetochore fibre dynamics outside the context of the spindle during anaphase

1 reference

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31 March 2020

Modulation of microtubule dynamics by drugs: a paradigm for the actions of cellular regulators

1 reference

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Structural insight into microtubule function

1 reference

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31 March 2020

Microtubule dynamics: taking aim at a moving target

1 reference

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31 March 2020

Determination of the size and chemical nature of the stabilizing "cap" at microtubule ends using modulators of polymerization dynamics

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31 March 2020

Concerning the chemical nature of tubulin subunits that cap and stabilize microtubules

1 reference

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Regulation of leading edge microtubule and actin dynamics downstream of Rac1

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Microtubule dynamics: new surprises from an old MAP.

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31 March 2020

An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin

1 reference

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31 March 2020

Surfing on microtubule ends

1 reference

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31 March 2020

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

1 reference

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31 March 2020

Cytoplasmic linker proteins promote microtubule rescue in vivo

1 reference

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31 March 2020

Microtubule dynamics and kinetochore function in mitosis

1 reference

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31 March 2020

Tubulin dynamics in cultured mammalian cells

1 reference

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31 March 2020

Cell cycle-dependent changes in microtubule dynamics in living cells expressing green fluorescent protein-alpha tubulin

1 reference

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31 March 2020

Microtubules are stabilized in confluent epithelial cells but not in fibroblasts

1 reference

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31 March 2020

Microtubule dynamics at the G2/M transition: abrupt breakdown of cytoplasmic microtubules at nuclear envelope breakdown and implications for spindle morphogenesis

1 reference

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31 March 2020

Kinetochores capture astral microtubules during chromosome attachment to the mitotic spindle: direct visualization in live newt lung cells

1 reference

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31 March 2020

Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

1 reference

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31 March 2020

Dynamic elastic behavior of alpha-satellite DNA domains visualized in situ in living human cells

1 reference

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31 March 2020

Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence

1 reference

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31 March 2020

Mitotic forces control a cell-cycle checkpoint

1 reference

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31 March 2020

Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint

1 reference

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31 March 2020

Cell cycle checkpoints: arresting progress in mitosis

1 reference

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31 March 2020

Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation

1 reference

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31 March 2020

Antimitotic peptides and depsipeptides

1 reference

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31 March 2020

Biochemistry of benzimidazole resistance

1 reference

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31 March 2020

Mechanism of action of antitumor drugs that interact with microtubules and tubulin

1 reference

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31 March 2020

The solid state, solution and tubulin-bound conformations of agents that promote microtubule stabilization

1 reference

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31 March 2020

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

1 reference

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31 March 2020

Taxol suppresses dynamics of individual microtubules in living human tumor cells

1 reference

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31 March 2020

Directional instability of kinetochore motility during chromosome congression and segregation in mitotic newt lung cells: a push-pull mechanism

1 reference

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31 March 2020

The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work

1 reference

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Vincristine revisited

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Chemotherapy-induced peripheral neuropathy

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Taxol neuropathy. Electrodiagnostic and sural nerve biopsy findings

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Interaction of vinblastine with steady-state microtubules in vitro

1 reference

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Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations.

1 reference

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31 March 2020

Stoichiometry of the vinblastine-induced self-association of calf brain tubulin.

1 reference

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Identification of a distinct class of vinblastine binding sites on microtubules

1 reference

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Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

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Promotion of microtubule assembly in vitro by taxol

1 reference

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How to make taxol from scratch

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Managing taxane toxicities

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Structure of tubulin at 6.5 A and location of the taxol-binding site.

1 reference

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31 March 2020

Substoichiometric binding of taxol suppresses microtubule dynamics.

1 reference

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31 March 2020

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

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Interactions of colchicine with tubulin

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Mechanism of inhibition of microtubule polymerization by colchicine: inhibitory potencies of unliganded colchicine and tubulin-colchicine complexes

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The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells

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Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death

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P-glycoprotein: from genomics to mechanism.

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Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators

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Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein

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Overcoming multidrug resistance in taxane chemotherapy

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Mechanisms of Taxol resistance related to microtubules.

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Purification and characterization of tubulin from parental and vincristine-resistant HOB1 lymphoma cells

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Characterization of a taxol-resistant human small-cell lung cancer cell line

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A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

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Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics

1 reference

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Altered expression of M beta 2, the class II beta-tubulin isotype, in a murine J774.2 cell line with a high level of taxol resistance

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31 March 2020

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes

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31 March 2020

Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism.

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Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry.

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Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol

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Stabilization of microtubule dynamics by estramustine by binding to a novel site in tubulin: A possible mechanistic basis for its antitumor action

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Phase II study of estramustine and vinblastine, two microtubule inhibitors, in hormone-refractory prostate cancer

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In vitro synergy of paclitaxel (Taxol) and vinorelbine (navelbine) against human melanoma cell lines

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Simultaneous combination of microtubule depolymerizing and stabilizing agents acts at low doses

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Combinations of paclitaxel and vinblastine and their effects on tubulin polymerization and cellular cytotoxicity: characterization of a synergistic schedule

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Interaction of the antitumor compound cryptophycin-52 with tubulin

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Interaction of cryptophycin 1 with tubulin and microtubules

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Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin

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Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B

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2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

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2-Methoxyestradiol, a promising anticancer agent

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Taxol binds to cellular microtubules

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Taxol binds to polymerized tubulin in vitro

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Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition

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First-line chemotherapy for NSCLC: an overview of relevant trials.

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Second line chemotherapy for NSCLC: establishing a gold standard

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The biology and medicinal chemistry of epothilones

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Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

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(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

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Anticancer therapy with novel tubulin-interacting drugs

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The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells

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