(Q28141740)

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Induction of vanilloid receptor channel activity by protein kinase C

scientific article (publication date: December 2000)

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Induction of vanilloid receptor channel activity by protein kinase C (English)

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L S Premkumar

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G P Ahern

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December 2000

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408

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6815

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985-90

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Impaired nociception and pain sensation in mice lacking the capsaicin receptor

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Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

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Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture

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Ruthenium red blocks the capsaicin-induced increase in intracellular calcium and activation of membrane currents in sensory neurones as well as the activation of peripheral nociceptors in vitro.

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Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons

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The capsaicin receptor: a heat-activated ion channel in the pain pathway

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The cloned capsaicin receptor integrates multiple pain-producing stimuli

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Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human

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A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice

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A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin

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Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful Heat

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Evidence that protein kinase C activation is involved in the excitatory and facilitatory effects of bradykinin on canine visceral nociceptors in vitro

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Bradykinin-induced depolarization of primary afferent nerve terminals in the neonatal rat spinal cord in vitro

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Bradykinin-induced stimulation of afferent fibres is mediated through protein kinase C

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Activation of protein kinase C augments peptide release from rat sensory neurons

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Activation of protein kinase C enhances peptide release from rat spinal cord slices

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Heat-induced release of CGRP from isolated rat skin and effects of bradykinin and the protein kinase C activator PMA

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Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats

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Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

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The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)

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Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances

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Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels

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Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

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